20% off SkinMedica + an Extra 20% off Auto-Replenishment. SHOP NOW
FREE US Shipping $50+ Auto-Replenishment 15% off First App Order Dermstore Rewards
iS Clinical

iS Clinical Active Serum (1 oz.)

A multi-tasking face serum that improves the appearance of aging, acne-prone and dull complexions.

Rewards members earn 740 points on this order. Register & opt in at checkout.

Join Dermstore Rewards

$148.00

Or 4 interest free payments of $37.00 with


In stock | Usually dispatched within 24 hours


Delivery & Returns
Free delivery is available on all orders over $50. Please see our shipping information page for all available delivery options.
If I'm not completely happy with my item?
Please see our returns policy.
*points earned on final checkout price, after any applied discounts.

Frequently Bought Together

iS Clinical Active Serum (1 oz.)

This item

iS Clinical Active Serum (1 oz.)

$148.00

Total Price:

$240.00

Other Customers Bought

Customer Reviews

4.63 stars out of a maximum of 5

5 stars rating 416 reviews

4 stars rating 46 reviews

3 stars rating 31 reviews

2 stars rating 11 reviews

1 stars rating 12 reviews

Top Customer Reviews

Reviews and results may vary from person to person. Customer reviews are and do not represent the views of The Hut Group.

LOVE the Active Serum

5 stars out of a maximum of 5

This serum is great for acne prone skin. I get the occasional pimple and this serum is something I apply when I have any acne or bumps on my face. It gives you a nice little sting when you put it on your skin- almost like menthol or rubbing alcohol. Which as a former noxzema teen user I love. It does has a strong scent, but it doesn't bother me because the scent doesn't last long once you place on your skin and add moisturizer. It doesn't dry out my dry skin and is just an all around awesome product. I highly recommend as a tool in your skincare arsenal.

by Anonymous Verified Purchase

Was this helpful?

An Amazing Product

5 stars out of a maximum of 5

I love how tingly this feels on the skin. It definitely helps blemishes heal very quick, and I have noticed a reduction in post inflammatory eurythmia from using it.

by Sydney

Was this helpful?

Amazingggg!

5 stars out of a maximum of 5

I never write reviews. Like ever. But Active Serum is AMAZING. I have always had acne-prone skin and last year started getting monthly facials to help with acne, melasma, dark spots, scarring, etc. The esthetician introduced me to IS Clinical and I started using the cleanser and Pro Heal. Cleanser is great and I liked Pro Heal but my skin was still breaking out. Spending $300 on a facial and buying these products, I expected better results. I stopped using Pro Heal and after reading reviews for Active Serum, I decided to give it a try. Ummm it's incredible! Believe the reviews. I have dry, sensitive skin and I can't believe the results I've gotten in only a few months of consistent use. My skin is smooth, zero acne (even while wearing a mask and being prone to chin/jawline breakouts), my melasma had faded so much and my pores are much smaller. Like... I went out without makeup for the first time in years and wasn't self-conscious whatsoever. Incredibly freeing. And I haven't felt the need to get a facial since December. My routine - Morning: For the first 8 weeks or so I washed my face (only warm water) in the morning and applied a dropper full of active serum (forehead, cheeks, neck, chin), used IS Clinical Moisturizing Complex and sunscreen. Evening: Wash face with cream cleanser, apply Active Serum again and Moisturizing Complex Now I have the same routine but only using Active Serum at night (trying to save some money) and I still use Moisturizing Complex/Sunscreen. I also tried the Copper Mist and spray it on if my skin feels dry. Seriously obsessed with IS Clinical.

by Anonymous Verified Purchase

Was this helpful?

Love this serum!

5 stars out of a maximum of 5

I have been using IS Clinical products since my friend told me about them. This serum has helped with my melasma and overall appearance of my complexion. I can now go without makeup without feel self conscious of my hyperpigmentation. I even was able to give up using my Retin A.

by Brooke Verified Purchase

Was this helpful?

My must have over all other serums

5 stars out of a maximum of 5

For those with Northern European ancestry(thin skin, freckles and sunburns easily, uneven pigmentation, dark pores, occasional breakouts) like me, this was God-sent. I never thought I would find something to address some of my daily skin struggles, and so effectively. Being a gay guy, wearing makeup is just plain weird to some people still, so we really have to work on our skin IMO. Also for men who struggle with having nice skin after shaving - this changed my life, I never struggle with shaving my face, or having a little stubble grow. My Facial hair even grows more beautifully! I would recommend this to anyone, as I feel it is at the core of why my skin has improved and been able to receive such good results with other products like human growth factors ect. 1 of 2 products I can truthfully say I will NEVER abandon.

by john Verified Purchase

Was this helpful?

Yesss! Love it

5 stars out of a maximum of 5

I absolutely love this product for my oily skin! I can feel it working and have noticed a big difference in my skin's texture. I am almost done with my first bottle and will be ordering a second bottle!

by Anonymous

Was this helpful?

So far so GOOD!

5 stars out of a maximum of 5

My skin has felt so soft and acne scars are fading a bit. I'm pregnant and love how this is safe and gentle. Will continue to use as my skin routine.

by Monique Verified Purchase

Was this helpful?

Expensive but worth it

5 stars out of a maximum of 5

I panic when I am running out of this! Seriously. Really helps keep my skin clear. It has been about 4 months of use and I can see a difference. I use this in the morning and the bottle lasts about 2 months. Highly recommend.

by Anonymous Verified Purchase

Was this helpful?

Not for my skin type imo

5 stars out of a maximum of 5

Maybe this is better for acne prone skin caused by oiliness. I have skin on the dry side, that breaks out based on what I use on my face or what I eat. This has alcohol in it and menthol to create that fake it's working tingly feeling, which neither is good for reactive skin. I think this one is a return.

by Paul Verified Purchase

Was this helpful?

Staple nighttime routine

5 stars out of a maximum of 5

I have been using this product for the last six months and there has been a noticeable difference in my acne and skin texture. It is a gentle exfoliating product. While it stings upon using, it dissipates quickly. Love this and will continue to use, even in the winter months.

by Elyssa Verified Purchase

Was this helpful?