FREE US Shipping $50+ Refer a Friend, Get $50 Shop with Afterpay Download Our App Dermstore Rewards
Summer Beauty Sale: Up to 20% off with code: SUN ends in
:Weeks
:Day
:Hours
:Minutes
:Seconds
iS Clinical

iS Clinical Active Serum (1 oz.)

A multi-tasking face serum that improves the appearance of aging, acne-prone and dull complexions.

Rewards members earn 740 points on this order. Register & opt in at checkout.

Join Dermstore Rewards

$148.00

Or 4 interest free payments of $37.00 with


In stock | Usually dispatched within 24 hours


Delivery & Returns
Free delivery is available on all orders over $50. Please see our shipping information page for all available delivery options.
If I'm not completely happy with my item?
Please see our returns policy.
*points earned on final checkout price, after any applied discounts.

Frequently Bought Together

iS Clinical Active Serum (1 oz.)

This item

iS Clinical Active Serum (1 oz.)

$148.00

Total Price:

$240.00

Other Customers Bought

Customer Reviews

4.63 stars out of a maximum of 5

5 stars rating 416 reviews

4 stars rating 46 reviews

3 stars rating 31 reviews

2 stars rating 11 reviews

1 stars rating 12 reviews

Top Customer Reviews

Reviews and results may vary from person to person. Customer reviews are and do not represent the views of The Hut Group.

My Skincare Must Have

5 stars out of a maximum of 5

This stuff is worth every penny. It clears up blemishes, and gives me the most even skin tone ever. It gets rid of my sun spots and redness. It's amazing!

by Anonymous Verified Purchase

Was this helpful?

Worth the hype

5 stars out of a maximum of 5

This product is excellent. You'll notice an improvement in skin texture and radiance, overnight!

by Anonymous

Was this helpful?

Impressive product, highly recommend

5 stars out of a maximum of 5

I love this active serum and use every other night! I switch off with the IS Clinical Hyro Serum, as it's a good balance for my skin. You can definitely use every night too! I saw a very quick difference in the size of my pores and texture of skin. Highly recommend.

by Anonymous Verified Purchase

Was this helpful?

Holy Grail Product

5 stars out of a maximum of 5

I know not all products are going to work for everyone, but this is an all-time favorite for me. I bought after thorough review deep-diving, and am so glad I did. I had relatively good skin up until late-in-life hormonal birth control-induced acne started wreaking havoc on my jawline. My sisters both suffer from cystic acne and have both completed Accutane twice. They swore by this for managing breakouts, and I tried it in conjunction with Spironolactone. I have a relatively simple routine (mild cleanser, hyaluronic serum, Cerave or Embryolisse moisturizer) and this is a nighttime must. Saved my skin. Still get occasional breakouts around my period but thats harder to manage. Feels sting-y when you apply but that's how you know it's working! Spilled the damn bottle once and lost about a third of my product. Tragic, bought another. No regrets.

by Anonymous Verified Purchase

Was this helpful?

Pretty darn good

4 stars out of a maximum of 5

I was actually pretty skeptical due to the ingredient list. Menthol? Alcohol? But so many glowing reviews I thought I'd treat myself and see if it lives up to the hype. It's only been 2 weeks, but so far so good. Haven't had any breakouts since using it, and pores seem less noticeable, so that's a win for me. 1 star off, because it is ridiculously priced, but so far it seems to be lasting a while. If I can get more than 4 months out of the bottle, I'll give it that last star.

by Anonymous Verified Purchase

Was this helpful?

Great Acne Serum

5 stars out of a maximum of 5

Dermstore sent me a small sample of this. It is a great product. Because of COVID, wearing mask as a healthcare worker has been breaking me out and giving me maskne. This product was a lifesaver. I used it few times and it made my acne disappear just after using it one or two times. It does tingle at first but it is normal because it means it is working. BUY THIS IF YOU HAVE ACNE AND UNEVEN COMPLEXION!!

by Anonymous

Was this helpful?

Great product, not great price

4 stars out of a maximum of 5

I love this product. I don't love the price. I've found the best usage is as an overnight spot treatment and it absolutely helps to minimize blemishes. But, I wouldn't say I notice a tremendous difference on days I use it vs days I don't, which is why I can't justify frequent repurchases at such a high price.

by Anonymous Verified Purchase

Was this helpful?

Lives Up to the Hype

5 stars out of a maximum of 5

I'm in my early 30s, have struggled with moderate to severe acne for almost 20 years, and have recently noticed fine lines emerging along with a haggard, dull skin texture. My aesthetician recommended this product to me to combat hyperpigmentation and active breakouts. After just one use, I saw immediate results. After a week, fine lines on my forehead became barely visible, reduced the size of active breakouts and/or completely got rid of the breakout, noticeably faded dark spots and inflammation left from previous breakouts. I have not had an issues with the product pilling if I wait until the serum completely dries before applying a moisturizer afterwards. In my opinion, it leaves a slight tacky texture when it has not fully dried. A little goes a long way (I started out using a 0.1ml trial size which last me 2 weeks of daily use). Overall, this serum leaves my skin radiantly glowing after each use. I use this product several times a week at night, and it does not leave my skin agitated or sensitive.

by Whitney

Was this helpful?

Good not great

4 stars out of a maximum of 5

I do like this product but I don't love it. I didn't use it daily but guessing with more regular use I would have gotten better results. I mixed it in with my routine and it didn't make things worse.

by Anonymous

Was this helpful?

Tingly feeling at first, but worth it!

5 stars out of a maximum of 5

Expensive, but worth it! When you first apply it to your face, it gives you the same tingly feeling as the DrunkElephant Babyfacial. I use it before i go to sleep and sometimes in the morning before I apply makeup. Th tingly feeling is oddly satisfying. Love it thus far!

by Anonymous Verified Purchase

Was this helpful?