Last Chance: Earn 2x points on SkinMedica | TWO Free Gifts when you spend $200+ on your purchase. SHOP NOW
FREE US Shipping $50+ Auto-Replenishment 15% off first App Order Dermstore Rewards
SkinMedica

SkinMedica TNS Advanced+ Serum (1 fl. oz.)

A powerful anti-aging serum that targets fine lines, deep wrinkles and sagging skin.

Rewards members earn 2950 points on this order. Register & opt in at checkout.

Join Dermstore Rewards

$295.00

Or 4 interest free payments of $73.75 with


In stock | Usually dispatched within 24 hours

Image 1 - Image of a skin serum bottle labeled TNS® ADVANCED+ SERUM with a background of glass beakers, featuring the text Next Generation Skin Rejuvenation and additional claims such as Clinically proven to address sagging skin, Smooths visible coarse wrinkles and fine lines, and Results start in just 2 weeks*.
Image 2 - Image showing a side-by-side comparison of a 60-year-old females face before and after using TNS Advanced+ serum, with the Before image on the left showing visible wrinkles and the After image on the right indicating smoother skin with marked improvements at week 2, alongside text detailing baseline and improvements.
Image 3 - Image shows a cream or gel texture with text highlighting key ingredients for skincare. Visible text includes: Key Ingredients TNS-MR An advanced formula to help you get age-defying results with: + NEXT-GENERATION GROWTH FACTOR BLEND Supports healthy skin functions + INNOVATIVE PEPTIDE COMPLEX Nourishes your skin Renessence (RSC) Advanced Specifically designed to support the results of the growth factor blend and includes: + MARINE EXTRACT Supports skin’s renewal process + GREEN MICROALGAE Supports collagen and elastin levels.
Image 4 - A sleek bottle of SkinMedica TNS Advanced+ Serum is displayed next to a small amount of the serum on a light background, with the text stating that in a clinical study, after 12 weeks, patients using the serum felt they looked up to 6 years younger.
Image 5 - A pair of hands holds a cosmetic bottle with instructions on its use, including details on when and how to apply the product, and visible text that reads: How to Use, WHEN TO APPLY, In the morning and evening after cleansing and toning, HOW TO APPLY, Before applying, invert and tap the bottom of the bottle, Remove the cap and press on the center of the pump to dispense onto the back of your hand using a bunny finger application, Blend the product together before applying, Avoid getting in eyes. If contact occurs, rinse eyes thoroughly with warm water.
Image 6 - Image of SkinMedica products arranged on a light background, including an AHA/BHA Exfoliating Cleanser, TNS Advanced+ Serum, Instant Bright Eye Cream, HA⁵ Hydra Collagen Replenish + Restore Hydrator, and Essential Defense Mineral Shield Broad Spectrum SPF 35 Sunscreen, with the text Complete Your SkinMedica Method Routine above them.

Delivery & Returns
Free delivery is available on all orders over $50. Please see our shipping information page for all available delivery options.
If I'm not completely happy with my item?
Please see our returns policy.
*points earned on final checkout price, after any applied discounts.

Frequently Bought Together

SkinMedica TNS Advanced+ Serum (1 fl. oz.)

This item

SkinMedica TNS Advanced+ Serum (1 fl. oz.)

$295.00

Total Price:

$479.00

Other Customers Bought

Customer Reviews

4.56 stars out of a maximum of 5

5 stars rating 441 reviews

4 stars rating 82 reviews

3 stars rating 32 reviews

2 stars rating 12 reviews

1 stars rating 19 reviews

Top Customer Reviews

Reviews and results may vary from person to person. Customer reviews are and do not represent the views of The Hut Group.

The best

4 stars out of a maximum of 5

This serum is the best. It's better than the original TNS serum bc it's far less stickier in my opinion. It's very expensive and that's why I gave it 4 out of 5 stars. They really need to think about the price.

by Jennifer Verified Purchase

Was this helpful?

Excellent product

5 stars out of a maximum of 5

This is a wonderful all in one product with growth factors, antioxidants, and peptides. If you want a fast routine where you get everything from one product this will definitely do the job. Excellent quality product!

by Staci

Was this helpful?

Love this Serum

5 stars out of a maximum of 5

I've been using this product on and off for a few years. When I didn't use the serum consistently, smoother skin and evened tone were the noticeable results. But, since I started using the serum religiously twice a day for about eight months, the serum has minimized my fine lines, specifically the lines on my forehead and my frow burrow lines. Full disclosure - I use other SkinMedica products in addition to the serum, so the results may be from the combination of products and not the serum alone. Also, advice from a middle-aged woman who has been using skincare products for over 20 years. Always manage your expectations when using anti-aging skincare products. The results are noticeable but not drastic.

by Michele

Was this helpful?

just magic

5 stars out of a maximum of 5

This product is just magic. I can't explain it. After only a few uses, my skin is so smooth and plump. It's like filler and botox in a bottle. I wish they were a little more transparent about what's in it and what it actually does but it's just great and unfortunately I'm addicted to this expensive serum. The biggest complaint I have is that I hate the packaging. You can't tell when you're running low to repurchase. I would also love if this brand offered a travel sized/small bottle. 

by rachel

Was this helpful?

Amazing serum

5 stars out of a maximum of 5

This  serum is a game changer. It’s the ultimate for beautiful skin, texture and clarity. Worth the price because it gives you the foundation of gorgeous skin for everything else you put on it. Once you try it, you will be hooked. Love love love. 

by Dawn Verified Purchase

Was this helpful?

It works! If you can make it last ...

4 stars out of a maximum of 5

The dispensing mechanism on this product is wasteful and awkward and should be changed. I ended up smashing the container open in the end and scooping up what was left with a Q-tip. Considering how much it costs, I didn't want to waste a drop. That said, it works. After a month of twice-daily usage, my skin is visibly improved, firmer and softer and smoother. So I ordered more and got on the subscription plan, which is worth it for a product this pricey. I just don't think there's anything else on the market quite like it. But I will be careful to use as little as possible this month.

by Judy M. Verified Purchase

Was this helpful?

Works great

4 stars out of a maximum of 5

Been using this for years (the regular version before the Advanced came out) and I believe it works- think I would definitely have more line than I do. I just wish it lasted longer for the price

by G Verified Purchase

Was this helpful?

I love this

5 stars out of a maximum of 5

After a microneedling session my aesthetician recommended using this product to promote skin health and beauty. Love it!

by Teresa

Was this helpful?

Spectacular Results! Just be patient!

5 stars out of a maximum of 5

This product is absolutely amazing. The price can be discouraging but you have to remember that this product is developed and created by actual scientists, who have their own data that they've collected and provide for you to see yourself. The ingredients are top of the line, patented, and extremely expensive to produce (especially Growth Factors). That being said- here are my thoughts on the "SkinMedica TNS Advanced+ Serum": You just have to be consistent, and patient. I didn't really notice the results until I was about a month in. One day I was doing my skin care regime and really looking at my skin and I had to take a step back and gasped. I couldn't believe how fresh, plump, even, clear, youthful, toned, smooth, and overall healthy my skin looked! I kept trying to think what I did differently that would make such a tremendous difference, and then I remembered it had been a little over 4 weeks since I started the TNS Advanced serum. That's the only logical explanation I can think of. It really does work wonders, you just have to give it time to do its job. What drove me nuts was that the day this happened was also the day I ran out! Needless to say I immediately ordered another one with express shipping, haha. This product is very easy to use. It's sanitary due to the inovative double pump. One pump is all you need per use. It's very light weight and absorbs into the skin immediately. It doesn't have a sticky or greasy feel once its absorbed. The smell is almost non existent. It's just a faint smell,  which is just a  result of the ingredients. If you dispense 1 pump, twice a day, this should last a month or so. I highly recommend getting the auto-monthly ship option so that you don't do what I did and run out just when it's starting to show it's working! Plus you save $$ on each bottle. This is definitely a staple in my skin care regime. You know it's working when other people are commenting and complimenting you. My boyfriend told me I looked younger the other day. He didn't understand why and doesn't know anything about the serum. He just looked at me and said "you look younger, did you do something with your hair?". Yeah, I think I'll stick with SkinMedica. 

by Kayla Verified Purchase

Was this helpful?

Amazing Results

5 stars out of a maximum of 5

I have seen a significant improvement in the texture of my skin. I get a lot of compliments and I am frequently asked about my skin care regime. 

by Kelly Verified Purchase

Was this helpful?