Added to your cart
SkinCeuticals Discoloration Defense (1 fl. oz.)
A skin-brightening serum clinically proven to correct dark spots.
-
4 installments of $27.00 with Klarna Learn more
-
4 installments of $27.00 with afterpay Learn more
SkinCeuticals' Discoloration Defense is clinically proven to reduce the appearance of dark spots and discoloration on the face. Powered by kojic acid, tranexamic acid and vitamin B3, this advanced formula is a hydroquinone-free skin brightening serum.
Key Ingredients:
- 3% Tranexamic Acid: minimizes the recurrence of discoloration and stubborn brown patches with continued use
- 1% Kojic Acid: naturally produced by certain fungi, kojic acid helps improve skin brightness
- 5% Niacinamide (Vitamin B3): a water-soluble vitamin that has been shown to help reduce the appearance of skin discoloration
- 5% HEPES: a synthetically-derived acid that activates natural enzymes in skin to help break the bonds that bind dead skin cells to the surface for even exfoliation
Key Benefits:
- Features a synergistic blend of anti-discoloration ingredients to reduce the appearance of skin discoloration, improve brightness, and minimize the reoccurrence of discoloration (with continued use)
- 60% average improvement in the appearance of stubborn brown patches
- Paraben-free, fragrance-free, silicone-free, gluten-free, and hydroquinone-free
- Ideal at-home complement to professional skin discoloration treatments, such as chemical peels or non-ablative laser; always consult with a physician for individual regimen recommendations
Clinical Studies:
In a 12-week clinical study*, Discoloration Defense significantly improved the appearance of key skin discoloration markers on Fitzpatrick I-IV skin tones:
- 60% average improvement in the appearance of stubborn brown patches
- 59% average improvement in the appearance of skin discoloration
- 81% average improvement in the appearance of post-acne marks
- 59% average improvement in the appearance of even skin tone
In a 12-week study** on deeper skin tones (Fitzpatrick V-VI), twice-daily application of Discoloration Defense demonstrated a statistically-significant improvement in the appearance of discoloration, post-inflammatory discoloration, and even skin tone:
- 33% reduction in hyperpigmentation at 12 weeks
- 34% reduction in post-inflammatory hyperpigmentation at 12 weeks
Learn more on the blog: How to incorporate this serum into your SkinCeuticals regimen.
*A 12-week, single-center, clinical study was conducted on 50 females, ages 25 to 60, Fitzpatrick I-IV, with mild-to-moderate facial skin discoloration, including stubborn dark spots, post-acne marks and uneven skin tone. Discoloration Defense was applied to the face twice a day in conjunction with a sunscreen. Efficacy and tolerability evaluations were conducted at baseline and at weeks 2, 4, 8, and 12.
**A 12-week, single-center, clinical study was conducted on 51 female subjects, Fitzpatrick V-VI, with visible signs of skin discoloration/hyperpigmentation, including post-inflammatory hyperpigmentation and melasma. Discoloration Defense was applied to the face twice a day in conjunction with a sunscreen. Efficacy and tolerability evaluations were conducted at baseline and at weeks 2, 4, 8, and 12.
Twice daily, apply three to five drops to face. For morning use, apply after a SkinCeuticals vitamin C serum and follow with a SkinCeuticals broad-spectrum SPF 50+ sunscreen and limit sun exposure while using this product. Do not use on irritated or broken skin. If irritation occurs, discontinue use.
Acne: Acne Scars
Application Area: Decollete, Face, Neck
Ideal for these Concerns: Acne, Aging Skin, Free Radical Damage, Hyperpigmentation, Scars, Sun Damage
Hyperpigmentation: Dark Spots, Melasma
Ingredient: Kojic Acid, Niacinamide
Preferences: Clean, Fragrance-Free, Gluten-Free, Paraben-Free, Phthalate-Free, Sulfate-Free
Skin Care: Skin Care Treatments
Skin Care Treatments: Face Serums
Skin Type: Acne-Prone Skin, Combination Skin, Dry Skin, Mature Skin, Normal Skin, Oily Skin, Sensitive Skin
Wellness | External Factors: UV Ray Protectors and Treatments
Aqua/Water, Butylene Glycol, Niacinamide, Hydroxyethylpiperazine Ethane Sulfonic Acid, Glycerin, Tranexamic Acid, Propylene Glycol, Hydroxyethyl Urea, Kojic Acid, Caprylyl Glycol, Allantoin, Chlorphenesin, Xanthan Gum, Disodium Edta.
- Correct
- SkinCeuticals
- 30ml
Frequently Bought Together



Total Price: $290.00
Add both to cart
SkinCeuticals Discoloration Defense (1 fl. oz.)
A skin-brightening serum clinically proven to correct dark spots.
Earn 540 reward points when purchasing this product as a rewards member*
-
-
Free delivery after your first order
-
You control the frequency
-
No commitment. Cancel or delay
-
Payment will be taken every month. months.
$108.00

$24 SkinCeuticals Gift


In stock
-
4 installments of $27.00 with Klarna Learn more
-
4 installments of $27.00 with afterpay Learn more
Delivery & Returns
Live Chat
Average connection time 25 secs
Average connection time 25 secs
SkinCeuticals' Discoloration Defense is clinically proven to reduce the appearance of dark spots and discoloration on the face. Powered by kojic acid, tranexamic acid and vitamin B3, this advanced formula is a hydroquinone-free skin brightening serum.
Key Ingredients:
- 3% Tranexamic Acid: minimizes the recurrence of discoloration and stubborn brown patches with continued use
- 1% Kojic Acid: naturally produced by certain fungi, kojic acid helps improve skin brightness
- 5% Niacinamide (Vitamin B3): a water-soluble vitamin that has been shown to help reduce the appearance of skin discoloration
- 5% HEPES: a synthetically-derived acid that activates natural enzymes in skin to help break the bonds that bind dead skin cells to the surface for even exfoliation
Key Benefits:
- Features a synergistic blend of anti-discoloration ingredients to reduce the appearance of skin discoloration, improve brightness, and minimize the reoccurrence of discoloration (with continued use)
- 60% average improvement in the appearance of stubborn brown patches
- Paraben-free, fragrance-free, silicone-free, gluten-free, and hydroquinone-free
- Ideal at-home complement to professional skin discoloration treatments, such as chemical peels or non-ablative laser; always consult with a physician for individual regimen recommendations
Clinical Studies:
In a 12-week clinical study*, Discoloration Defense significantly improved the appearance of key skin discoloration markers on Fitzpatrick I-IV skin tones:
- 60% average improvement in the appearance of stubborn brown patches
- 59% average improvement in the appearance of skin discoloration
- 81% average improvement in the appearance of post-acne marks
- 59% average improvement in the appearance of even skin tone
In a 12-week study** on deeper skin tones (Fitzpatrick V-VI), twice-daily application of Discoloration Defense demonstrated a statistically-significant improvement in the appearance of discoloration, post-inflammatory discoloration, and even skin tone:
- 33% reduction in hyperpigmentation at 12 weeks
- 34% reduction in post-inflammatory hyperpigmentation at 12 weeks
Learn more on the blog: How to incorporate this serum into your SkinCeuticals regimen.
*A 12-week, single-center, clinical study was conducted on 50 females, ages 25 to 60, Fitzpatrick I-IV, with mild-to-moderate facial skin discoloration, including stubborn dark spots, post-acne marks and uneven skin tone. Discoloration Defense was applied to the face twice a day in conjunction with a sunscreen. Efficacy and tolerability evaluations were conducted at baseline and at weeks 2, 4, 8, and 12.
**A 12-week, single-center, clinical study was conducted on 51 female subjects, Fitzpatrick V-VI, with visible signs of skin discoloration/hyperpigmentation, including post-inflammatory hyperpigmentation and melasma. Discoloration Defense was applied to the face twice a day in conjunction with a sunscreen. Efficacy and tolerability evaluations were conducted at baseline and at weeks 2, 4, 8, and 12.
Twice daily, apply three to five drops to face. For morning use, apply after a SkinCeuticals vitamin C serum and follow with a SkinCeuticals broad-spectrum SPF 50+ sunscreen and limit sun exposure while using this product. Do not use on irritated or broken skin. If irritation occurs, discontinue use.
Acne: Acne Scars
Application Area: Decollete, Face, Neck
Ideal for these Concerns: Acne, Aging Skin, Free Radical Damage, Hyperpigmentation, Scars, Sun Damage
Hyperpigmentation: Dark Spots, Melasma
Ingredient: Kojic Acid, Niacinamide
Preferences: Clean, Fragrance-Free, Gluten-Free, Paraben-Free, Phthalate-Free, Sulfate-Free
Skin Care: Skin Care Treatments
Skin Care Treatments: Face Serums
Skin Type: Acne-Prone Skin, Combination Skin, Dry Skin, Mature Skin, Normal Skin, Oily Skin, Sensitive Skin
Wellness | External Factors: UV Ray Protectors and Treatments
Aqua/Water, Butylene Glycol, Niacinamide, Hydroxyethylpiperazine Ethane Sulfonic Acid, Glycerin, Tranexamic Acid, Propylene Glycol, Hydroxyethyl Urea, Kojic Acid, Caprylyl Glycol, Allantoin, Chlorphenesin, Xanthan Gum, Disodium Edta.
- Correct
- SkinCeuticals
- 30ml
Frequently Bought Together



Total Price: $290.00
Add both to cart
Customer Reviews
Top Customer Reviews
Where reviews refer to beauty products or supplements, results may vary from person to person. Customer reviews are independent and do not represent the views of Dermstore.
Reward members earn 50 points for every review written on verified purchases.
Ms
Used this product for 6 months and didn’t see any difference. I wish I liked it because is one of the inexpensive serum form SkinCeuticals.
Report this reviewToo Soon
It’s too soon to tell, I’ve been using for a month now, I haven’t seen a significant difference yet.
Report this reviewIt works!
SkinCeuticals Discoloration Defense actually works! I only use 2 to 3 drops in the morning and 2 to 3 drops in the evening. A small amount goes a long way. My skins looks brighter and the brown and reddish spots have considerably faded after only using for a couple of weeks. This product is worth the money. I didn't give it 5 starts because I haven't used it long enough to see if the spots get even lighter and go away completely.
Report this reviewHelped a lot!
I have been using this for a month and my skin already looks clearer. I would definitely buy again.
Report this reviewGreat serum
I love this product, i I have seen the improvement of my skin, smothered texture and some small spots are gone, be constant, this product work 👍
Report this reviewImmediate Change
Have been using this for years. I see immediate results following application as the color of the serum helps blur skin tone. Over time it reduces discoloration of the skin. Goes on easily after vitamin C serum and before moisturizer. Soaks in right away. Definitely recommend!
Report this reviewJust meh
I didn’t notice this helping me with any discoloration. The CE Ferulic serum is way better at reducing discoloration and dark spots. Would not repurchase.
Report this reviewNo significant change
I did not see any significant lightening of dark spots. For the price, I expected it to work as well as prescription dark spot treatments.
Report this review