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SkinCeuticals Discoloration Defense (1 fl. oz.)
A skin-brightening serum clinically proven to correct dark spots.
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4 installments of $27.00 with Klarna Learn more
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4 installments of $27.00 with afterpay Learn more
SkinCeuticals' Discoloration Defense is clinically proven to reduce the appearance of dark spots and discoloration on the face. Powered by kojic acid, tranexamic acid and vitamin B3, this advanced formula is a hydroquinone-free skin brightening serum.
Key Ingredients:
- 3% Tranexamic Acid: minimizes the recurrence of discoloration and stubborn brown patches with continued use
- 1% Kojic Acid: naturally produced by certain fungi, kojic acid helps improve skin brightness
- 5% Niacinamide (Vitamin B3): a water-soluble vitamin that has been shown to help reduce the appearance of skin discoloration
- 5% HEPES: a synthetically-derived acid that activates natural enzymes in skin to help break the bonds that bind dead skin cells to the surface for even exfoliation
Key Benefits:
- Features a synergistic blend of anti-discoloration ingredients to reduce the appearance of skin discoloration, improve brightness, and minimize the reoccurrence of discoloration (with continued use)
- 60% average improvement in the appearance of stubborn brown patches
- Paraben-free, fragrance-free, silicone-free, gluten-free, and hydroquinone-free
- Ideal at-home complement to professional skin discoloration treatments, such as chemical peels or non-ablative laser; always consult with a physician for individual regimen recommendations
Clinical Studies:
In a 12-week clinical study*, Discoloration Defense significantly improved the appearance of key skin discoloration markers on Fitzpatrick I-IV skin tones:
- 60% average improvement in the appearance of stubborn brown patches
- 59% average improvement in the appearance of skin discoloration
- 81% average improvement in the appearance of post-acne marks
- 59% average improvement in the appearance of even skin tone
In a 12-week study** on deeper skin tones (Fitzpatrick V-VI), twice-daily application of Discoloration Defense demonstrated a statistically-significant improvement in the appearance of discoloration, post-inflammatory discoloration, and even skin tone:
- 33% reduction in hyperpigmentation at 12 weeks
- 34% reduction in post-inflammatory hyperpigmentation at 12 weeks
Learn more on the blog: How to incorporate this serum into your SkinCeuticals regimen.
*A 12-week, single-center, clinical study was conducted on 50 females, ages 25 to 60, Fitzpatrick I-IV, with mild-to-moderate facial skin discoloration, including stubborn dark spots, post-acne marks and uneven skin tone. Discoloration Defense was applied to the face twice a day in conjunction with a sunscreen. Efficacy and tolerability evaluations were conducted at baseline and at weeks 2, 4, 8, and 12.
**A 12-week, single-center, clinical study was conducted on 51 female subjects, Fitzpatrick V-VI, with visible signs of skin discoloration/hyperpigmentation, including post-inflammatory hyperpigmentation and melasma. Discoloration Defense was applied to the face twice a day in conjunction with a sunscreen. Efficacy and tolerability evaluations were conducted at baseline and at weeks 2, 4, 8, and 12.
Twice daily, apply three to five drops to face. For morning use, apply after a SkinCeuticals vitamin C serum and follow with a SkinCeuticals broad-spectrum SPF 50+ sunscreen and limit sun exposure while using this product. Do not use on irritated or broken skin. If irritation occurs, discontinue use.
Acne: Acne Scars
Application Area: Decollete, Face, Neck
Ideal for these Concerns: Acne, Aging Skin, Free Radical Damage, Hyperpigmentation, Scars, Sun Damage
Hyperpigmentation: Dark Spots, Melasma
Ingredient: Kojic Acid, Niacinamide
Preferences: Clean, Fragrance-Free, Gluten-Free, Paraben-Free, Phthalate-Free, Sulfate-Free
Skin Care: Skin Care Treatments
Skin Care Treatments: Face Serums
Skin Type: Acne-Prone Skin, Combination Skin, Dry Skin, Mature Skin, Normal Skin, Oily Skin, Sensitive Skin
Wellness | External Factors: UV Ray Protectors and Treatments
Aqua/Water, Butylene Glycol, Niacinamide, Hydroxyethylpiperazine Ethane Sulfonic Acid, Glycerin, Tranexamic Acid, Propylene Glycol, Hydroxyethyl Urea, Kojic Acid, Caprylyl Glycol, Allantoin, Chlorphenesin, Xanthan Gum, Disodium Edta.
- Correct
- SkinCeuticals
- 30ml
Frequently Bought Together



Total Price: $290.00
Add both to cart
SkinCeuticals Discoloration Defense (1 fl. oz.)
A skin-brightening serum clinically proven to correct dark spots.
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4 installments of $27.00 with Klarna Learn more
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4 installments of $27.00 with afterpay Learn more
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SkinCeuticals' Discoloration Defense is clinically proven to reduce the appearance of dark spots and discoloration on the face. Powered by kojic acid, tranexamic acid and vitamin B3, this advanced formula is a hydroquinone-free skin brightening serum.
Key Ingredients:
- 3% Tranexamic Acid: minimizes the recurrence of discoloration and stubborn brown patches with continued use
- 1% Kojic Acid: naturally produced by certain fungi, kojic acid helps improve skin brightness
- 5% Niacinamide (Vitamin B3): a water-soluble vitamin that has been shown to help reduce the appearance of skin discoloration
- 5% HEPES: a synthetically-derived acid that activates natural enzymes in skin to help break the bonds that bind dead skin cells to the surface for even exfoliation
Key Benefits:
- Features a synergistic blend of anti-discoloration ingredients to reduce the appearance of skin discoloration, improve brightness, and minimize the reoccurrence of discoloration (with continued use)
- 60% average improvement in the appearance of stubborn brown patches
- Paraben-free, fragrance-free, silicone-free, gluten-free, and hydroquinone-free
- Ideal at-home complement to professional skin discoloration treatments, such as chemical peels or non-ablative laser; always consult with a physician for individual regimen recommendations
Clinical Studies:
In a 12-week clinical study*, Discoloration Defense significantly improved the appearance of key skin discoloration markers on Fitzpatrick I-IV skin tones:
- 60% average improvement in the appearance of stubborn brown patches
- 59% average improvement in the appearance of skin discoloration
- 81% average improvement in the appearance of post-acne marks
- 59% average improvement in the appearance of even skin tone
In a 12-week study** on deeper skin tones (Fitzpatrick V-VI), twice-daily application of Discoloration Defense demonstrated a statistically-significant improvement in the appearance of discoloration, post-inflammatory discoloration, and even skin tone:
- 33% reduction in hyperpigmentation at 12 weeks
- 34% reduction in post-inflammatory hyperpigmentation at 12 weeks
Learn more on the blog: How to incorporate this serum into your SkinCeuticals regimen.
*A 12-week, single-center, clinical study was conducted on 50 females, ages 25 to 60, Fitzpatrick I-IV, with mild-to-moderate facial skin discoloration, including stubborn dark spots, post-acne marks and uneven skin tone. Discoloration Defense was applied to the face twice a day in conjunction with a sunscreen. Efficacy and tolerability evaluations were conducted at baseline and at weeks 2, 4, 8, and 12.
**A 12-week, single-center, clinical study was conducted on 51 female subjects, Fitzpatrick V-VI, with visible signs of skin discoloration/hyperpigmentation, including post-inflammatory hyperpigmentation and melasma. Discoloration Defense was applied to the face twice a day in conjunction with a sunscreen. Efficacy and tolerability evaluations were conducted at baseline and at weeks 2, 4, 8, and 12.
Twice daily, apply three to five drops to face. For morning use, apply after a SkinCeuticals vitamin C serum and follow with a SkinCeuticals broad-spectrum SPF 50+ sunscreen and limit sun exposure while using this product. Do not use on irritated or broken skin. If irritation occurs, discontinue use.
Acne: Acne Scars
Application Area: Decollete, Face, Neck
Ideal for these Concerns: Acne, Aging Skin, Free Radical Damage, Hyperpigmentation, Scars, Sun Damage
Hyperpigmentation: Dark Spots, Melasma
Ingredient: Kojic Acid, Niacinamide
Preferences: Clean, Fragrance-Free, Gluten-Free, Paraben-Free, Phthalate-Free, Sulfate-Free
Skin Care: Skin Care Treatments
Skin Care Treatments: Face Serums
Skin Type: Acne-Prone Skin, Combination Skin, Dry Skin, Mature Skin, Normal Skin, Oily Skin, Sensitive Skin
Wellness | External Factors: UV Ray Protectors and Treatments
Aqua/Water, Butylene Glycol, Niacinamide, Hydroxyethylpiperazine Ethane Sulfonic Acid, Glycerin, Tranexamic Acid, Propylene Glycol, Hydroxyethyl Urea, Kojic Acid, Caprylyl Glycol, Allantoin, Chlorphenesin, Xanthan Gum, Disodium Edta.
- Correct
- SkinCeuticals
- 30ml
Frequently Bought Together



Total Price: $290.00
Add both to cart
Customer Reviews
Top Customer Reviews
Where reviews refer to beauty products or supplements, results may vary from person to person. Customer reviews are independent and do not represent the views of Dermstore.
Reward members earn 50 points for every review written on verified purchases.
Still testing.
Been using for a few months I love the SkinCeuticals line. Trying this discoloration defense. Not sure how effective it is yet.
Report this reviewFading age spots
Wether it be age spot or sun damage this magical serum is fading them away and quickly ❤️❤️
Report this reviewDiscoloration Defense
I purchase my skin care products from Skin Ceuticals and the Dermstore. The serum products when first opened are a clear light yellow and over time transition to a dark orange color. To my surprise, the product I purchased from the Dermstore was the dark orange color when I first received it..I’m not sure if the cap open or what happened, but I am dissatisfied with my purchase.
Report this reviewSlowly but surely
This product glides on easily and absorbs quickly. I think it's going to take some time to see real results but it has a lovely feel and marries well with the other items in my AM routine.
Report this reviewDisappointed
Received the serum and it was dark brown in color. Initially I thought that it was normal, and continued to use it . Now I am noticing that my facial skin is at least 2 shades darker than my chest, like I have been in the sun and tanned. I wear spf 46 everyday, even while I am indoors. Very disappointed with the quality control. Who knows how long this has been on the shelf.
Report this reviewConcerns
Why this product is dark orange like is oxides? I opened the bottle soon I saw the liquid I realized that it is must be an expired product already.
Report this reviewDefective product
I have been using SkinCeuticals for years and have always been satisfied with the products. I order from both Dermstore and directly from SkinCeuticals. I recently purchased Discoloration Defense from the Dermstore and to my surprise the serum was already orange. Usually, the serum products like C Feuric begin a light clear yellow and then overtime they become orange. I feel the product may have been previously opened or ??? I am very disappointed
Report this reviewIt works
This has helped me with my dark spots and post acne marks. I originally received this as a sample and just recently purchased the full size.
Report this reviewWorks Wonder
Purchased this after suffering from an adult hormonal acne flare that left post-inflammatory hyperpigmentation around my chin and jaw area. I tried Musely to help fade the dark spots, but it didn’t work for me. Left my skin irritated and caused more whiteheads. Read reviews on Discoloration Defense and decided to try it out. It’s been about 4 weeks and the spots are fading really well without any skin irritation. It’s also been helping minimize blackheads and whiteheads, especially when paired with Skinceuticals Retinol 0.5% every other night. Will definitely repurchase.
Report this reviewDark spots be gone
Love this serum. Makes me look bright, even toned, and refreshed. Has helped tremendously with my dark spots
Report this review