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SkinCeuticals Discoloration Defense (1 fl. oz.)
A skin-brightening serum clinically proven to correct dark spots.
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4 installments of $25.50 with Klarna Learn more
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4 installments of $25.50 with afterpay Learn more
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4 installments of $25.50 with sezzle Learn more
SkinCeuticals' Discoloration Defense is clinically proven to reduce the appearance of dark spots and discoloration on the face. Powered by kojic acid, tranexamic acid and vitamin B3, this advanced formula is a hydroquinone-free skin brightening serum.
Key Ingredients:
- 3% Tranexamic Acid: minimizes the recurrence of discoloration and stubborn brown patches with continued use
- 1% Kojic Acid: naturally produced by certain fungi, kojic acid helps improve skin brightness
- 5% Niacinamide (Vitamin B3): a water-soluble vitamin that has been shown to help reduce the appearance of skin discoloration
- 5% HEPES: a synthetically-derived acid that activates natural enzymes in skin to help break the bonds that bind dead skin cells to the surface for even exfoliation
Key Benefits:
- Features a synergistic blend of anti-discoloration ingredients to reduce the appearance of skin discoloration, improve brightness, and minimize the reoccurrence of discoloration (with continued use)
- 60% average improvement in the appearance of stubborn brown patches
- Paraben-free, fragrance-free, silicone-free, gluten-free, and hydroquinone-free
- Ideal at-home complement to professional skin discoloration treatments, such as chemical peels or non-ablative laser; always consult with a physician for individual regimen recommendations
Clinical Studies:
In a 12-week clinical study*, Discoloration Defense significantly improved the appearance of key skin discoloration markers on Fitzpatrick I-IV skin tones:
- 60% average improvement in the appearance of stubborn brown patches
- 59% average improvement in the appearance of skin discoloration
- 81% average improvement in the appearance of post-acne marks
- 59% average improvement in the appearance of even skin tone
In a 12-week study** on deeper skin tones (Fitzpatrick V-VI), twice-daily application of Discoloration Defense demonstrated a statistically-significant improvement in the appearance of discoloration, post-inflammatory discoloration, and even skin tone:
- 33% reduction in hyperpigmentation at 12 weeks
- 34% reduction in post-inflammatory hyperpigmentation at 12 weeks
Learn more on the blog: How to incorporate this serum into your SkinCeuticals regimen.
*A 12-week, single-center, clinical study was conducted on 50 females, ages 25 to 60, Fitzpatrick I-IV, with mild-to-moderate facial skin discoloration, including stubborn dark spots, post-acne marks and uneven skin tone. Discoloration Defense was applied to the face twice a day in conjunction with a sunscreen. Efficacy and tolerability evaluations were conducted at baseline and at weeks 2, 4, 8, and 12.
**A 12-week, single-center, clinical study was conducted on 51 female subjects, Fitzpatrick V-VI, with visible signs of skin discoloration/hyperpigmentation, including post-inflammatory hyperpigmentation and melasma. Discoloration Defense was applied to the face twice a day in conjunction with a sunscreen. Efficacy and tolerability evaluations were conducted at baseline and at weeks 2, 4, 8, and 12.
Twice daily, apply three to five drops to face. For morning use, apply after a SkinCeuticals vitamin C serum and follow with a SkinCeuticals broad-spectrum SPF 50+ sunscreen and limit sun exposure while using this product. Do not use on irritated or broken skin. If irritation occurs, discontinue use.
Acne: Acne Scars
Application Area: Decollete, Face, Neck
Ideal for these Concerns: Acne, Aging Skin, Free Radical Damage, Hyperpigmentation, Scars, Sun Damage
Hyperpigmentation: Dark Spots, Melasma
Ingredient: Kojic Acid, Niacinamide
Preferences: Clean, Fragrance-Free, Gluten-Free, Paraben-Free, Phthalate-Free, Sulfate-Free
Skin Care: Skin Care Treatments
Skin Care Treatments: Face Serums
Skin Type: Acne-Prone Skin, Combination Skin, Dry Skin, Mature Skin, Normal Skin, Oily Skin, Sensitive Skin
Wellness | External Factors: UV Ray Protectors and Treatments
Aqua/Water, Butylene Glycol, Niacinamide, Hydroxyethylpiperazine Ethane Sulfonic Acid, Glycerin, Tranexamic Acid, Propylene Glycol, Hydroxyethyl Urea, Kojic Acid, Caprylyl Glycol, Allantoin, Chlorphenesin, Xanthan Gum, Disodium Edta.
Frequently Bought Together



Total Price: $271.00
Add both to cart
SkinCeuticals Discoloration Defense (1 fl. oz.)
A skin-brightening serum clinically proven to correct dark spots.
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4 installments of $25.50 with Klarna Learn more
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SkinCeuticals' Discoloration Defense is clinically proven to reduce the appearance of dark spots and discoloration on the face. Powered by kojic acid, tranexamic acid and vitamin B3, this advanced formula is a hydroquinone-free skin brightening serum.
Key Ingredients:
- 3% Tranexamic Acid: minimizes the recurrence of discoloration and stubborn brown patches with continued use
- 1% Kojic Acid: naturally produced by certain fungi, kojic acid helps improve skin brightness
- 5% Niacinamide (Vitamin B3): a water-soluble vitamin that has been shown to help reduce the appearance of skin discoloration
- 5% HEPES: a synthetically-derived acid that activates natural enzymes in skin to help break the bonds that bind dead skin cells to the surface for even exfoliation
Key Benefits:
- Features a synergistic blend of anti-discoloration ingredients to reduce the appearance of skin discoloration, improve brightness, and minimize the reoccurrence of discoloration (with continued use)
- 60% average improvement in the appearance of stubborn brown patches
- Paraben-free, fragrance-free, silicone-free, gluten-free, and hydroquinone-free
- Ideal at-home complement to professional skin discoloration treatments, such as chemical peels or non-ablative laser; always consult with a physician for individual regimen recommendations
Clinical Studies:
In a 12-week clinical study*, Discoloration Defense significantly improved the appearance of key skin discoloration markers on Fitzpatrick I-IV skin tones:
- 60% average improvement in the appearance of stubborn brown patches
- 59% average improvement in the appearance of skin discoloration
- 81% average improvement in the appearance of post-acne marks
- 59% average improvement in the appearance of even skin tone
In a 12-week study** on deeper skin tones (Fitzpatrick V-VI), twice-daily application of Discoloration Defense demonstrated a statistically-significant improvement in the appearance of discoloration, post-inflammatory discoloration, and even skin tone:
- 33% reduction in hyperpigmentation at 12 weeks
- 34% reduction in post-inflammatory hyperpigmentation at 12 weeks
Learn more on the blog: How to incorporate this serum into your SkinCeuticals regimen.
*A 12-week, single-center, clinical study was conducted on 50 females, ages 25 to 60, Fitzpatrick I-IV, with mild-to-moderate facial skin discoloration, including stubborn dark spots, post-acne marks and uneven skin tone. Discoloration Defense was applied to the face twice a day in conjunction with a sunscreen. Efficacy and tolerability evaluations were conducted at baseline and at weeks 2, 4, 8, and 12.
**A 12-week, single-center, clinical study was conducted on 51 female subjects, Fitzpatrick V-VI, with visible signs of skin discoloration/hyperpigmentation, including post-inflammatory hyperpigmentation and melasma. Discoloration Defense was applied to the face twice a day in conjunction with a sunscreen. Efficacy and tolerability evaluations were conducted at baseline and at weeks 2, 4, 8, and 12.
Twice daily, apply three to five drops to face. For morning use, apply after a SkinCeuticals vitamin C serum and follow with a SkinCeuticals broad-spectrum SPF 50+ sunscreen and limit sun exposure while using this product. Do not use on irritated or broken skin. If irritation occurs, discontinue use.
Acne: Acne Scars
Application Area: Decollete, Face, Neck
Ideal for these Concerns: Acne, Aging Skin, Free Radical Damage, Hyperpigmentation, Scars, Sun Damage
Hyperpigmentation: Dark Spots, Melasma
Ingredient: Kojic Acid, Niacinamide
Preferences: Clean, Fragrance-Free, Gluten-Free, Paraben-Free, Phthalate-Free, Sulfate-Free
Skin Care: Skin Care Treatments
Skin Care Treatments: Face Serums
Skin Type: Acne-Prone Skin, Combination Skin, Dry Skin, Mature Skin, Normal Skin, Oily Skin, Sensitive Skin
Wellness | External Factors: UV Ray Protectors and Treatments
Aqua/Water, Butylene Glycol, Niacinamide, Hydroxyethylpiperazine Ethane Sulfonic Acid, Glycerin, Tranexamic Acid, Propylene Glycol, Hydroxyethyl Urea, Kojic Acid, Caprylyl Glycol, Allantoin, Chlorphenesin, Xanthan Gum, Disodium Edta.
Frequently Bought Together



Total Price: $271.00
Add both to cart
Customer Reviews
Top Customer Reviews
Where reviews refer to beauty products or supplements, results may vary from person to person. Customer reviews are independent and do not represent the views of Dermstore.
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Works Well
Been using Discoloration Defense for over 2 years and it’s done a good job at lightening most face discoloration for me; reason for 4 stars. I’d give it 5 stars if it took care of all my face discoloration. Easy to use, pleasant smell and because of the slight color it instantly makes the skin brighter and more even toned.
Report this reviewA must in my cabinet
This pairs well with skinceuticals phloretin cf! I have sensitive skin and it doesn’t both me. Just one thing…it smells like hotdog juice🤮
Report this reviewAmazing
This product is great for KP and is also fantastic at removing self-tanner that's a bit stubborn (I let the profuct sit on my skin for a bit longer than recommend) and use a gentle exfoliating to wipe it off. 10 out of 10 for this product
Report this reviewI love it
I have brown skin and it stains easily when I get a pimple and this product helps me reduce spots
Report this reviewFor glowing skin
This is a great product, but needs time to work. I started seeing results in acne marks after a few weeks of consistent twice daily use. Extra sun protection is a must while using.
Report this reviewUnimpressed
I was very dissatisfied with this product. It smelled terrible and made my face itch. I used the whole bottle and didn’t notice even a slight difference
Report this reviewLight and easy to use
I think this product is light and goes on easy; I haven't used it for a month so I can't say if is doing anything to help with my discoloration. I plan to keep using it until I finish this first bottle and will try at least one more bottle before I decide whether it is helping with my discoloration.
Report this reviewPerhaps
Gal that performs exfoliation tells me that she sees results and she did not sell this product to me. Me. I say "perhaps."
Report this reviewBuy this now!
I should have taken before and after pics! I have only been using for 2 weeks, but can tell a difference! A little goes a long way! Worth the price!
Report this review