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SkinCeuticals Discoloration Defense (1 fl. oz.)
A skin-brightening serum clinically proven to correct dark spots.
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4 installments of $27.00 with Klarna Learn more
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4 installments of $27.00 with afterpay Learn more
SkinCeuticals' Discoloration Defense is clinically proven to reduce the appearance of dark spots and discoloration on the face. Powered by kojic acid, tranexamic acid and vitamin B3, this advanced formula is a hydroquinone-free skin brightening serum.
Key Ingredients:
- 3% Tranexamic Acid: minimizes the recurrence of discoloration and stubborn brown patches with continued use
- 1% Kojic Acid: naturally produced by certain fungi, kojic acid helps improve skin brightness
- 5% Niacinamide (Vitamin B3): a water-soluble vitamin that has been shown to help reduce the appearance of skin discoloration
- 5% HEPES: a synthetically-derived acid that activates natural enzymes in skin to help break the bonds that bind dead skin cells to the surface for even exfoliation
Key Benefits:
- Features a synergistic blend of anti-discoloration ingredients to reduce the appearance of skin discoloration, improve brightness, and minimize the reoccurrence of discoloration (with continued use)
- 60% average improvement in the appearance of stubborn brown patches
- Paraben-free, fragrance-free, silicone-free, gluten-free, and hydroquinone-free
- Ideal at-home complement to professional skin discoloration treatments, such as chemical peels or non-ablative laser; always consult with a physician for individual regimen recommendations
Clinical Studies:
In a 12-week clinical study*, Discoloration Defense significantly improved the appearance of key skin discoloration markers on Fitzpatrick I-IV skin tones:
- 60% average improvement in the appearance of stubborn brown patches
- 59% average improvement in the appearance of skin discoloration
- 81% average improvement in the appearance of post-acne marks
- 59% average improvement in the appearance of even skin tone
In a 12-week study** on deeper skin tones (Fitzpatrick V-VI), twice-daily application of Discoloration Defense demonstrated a statistically-significant improvement in the appearance of discoloration, post-inflammatory discoloration, and even skin tone:
- 33% reduction in hyperpigmentation at 12 weeks
- 34% reduction in post-inflammatory hyperpigmentation at 12 weeks
Learn more on the blog: How to incorporate this serum into your SkinCeuticals regimen.
*A 12-week, single-center, clinical study was conducted on 50 females, ages 25 to 60, Fitzpatrick I-IV, with mild-to-moderate facial skin discoloration, including stubborn dark spots, post-acne marks and uneven skin tone. Discoloration Defense was applied to the face twice a day in conjunction with a sunscreen. Efficacy and tolerability evaluations were conducted at baseline and at weeks 2, 4, 8, and 12.
**A 12-week, single-center, clinical study was conducted on 51 female subjects, Fitzpatrick V-VI, with visible signs of skin discoloration/hyperpigmentation, including post-inflammatory hyperpigmentation and melasma. Discoloration Defense was applied to the face twice a day in conjunction with a sunscreen. Efficacy and tolerability evaluations were conducted at baseline and at weeks 2, 4, 8, and 12.
Twice daily, apply three to five drops to face. For morning use, apply after a SkinCeuticals vitamin C serum and follow with a SkinCeuticals broad-spectrum SPF 50+ sunscreen and limit sun exposure while using this product. Do not use on irritated or broken skin. If irritation occurs, discontinue use.
Acne: Acne Scars
Application Area: Decollete, Face, Neck
Ideal for these Concerns: Acne, Aging Skin, Free Radical Damage, Hyperpigmentation, Scars, Sun Damage
Hyperpigmentation: Dark Spots, Melasma
Ingredient: Kojic Acid, Niacinamide
Preferences: Clean, Fragrance-Free, Gluten-Free, Paraben-Free, Phthalate-Free, Sulfate-Free
Skin Care: Skin Care Treatments
Skin Care Treatments: Face Serums
Skin Type: Acne-Prone Skin, Combination Skin, Dry Skin, Mature Skin, Normal Skin, Oily Skin, Sensitive Skin
Wellness | External Factors: UV Ray Protectors and Treatments
Aqua/Water, Butylene Glycol, Niacinamide, Hydroxyethylpiperazine Ethane Sulfonic Acid, Glycerin, Tranexamic Acid, Propylene Glycol, Hydroxyethyl Urea, Kojic Acid, Caprylyl Glycol, Allantoin, Chlorphenesin, Xanthan Gum, Disodium Edta.
- Correct
- SkinCeuticals
- 30ml
Frequently Bought Together



Total Price: $290.00
Add both to cart
SkinCeuticals Discoloration Defense (1 fl. oz.)
A skin-brightening serum clinically proven to correct dark spots.
Earn 540 reward points when purchasing this product as a rewards member*
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$108.00
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4 installments of $27.00 with Klarna Learn more
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4 installments of $27.00 with afterpay Learn more
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SkinCeuticals' Discoloration Defense is clinically proven to reduce the appearance of dark spots and discoloration on the face. Powered by kojic acid, tranexamic acid and vitamin B3, this advanced formula is a hydroquinone-free skin brightening serum.
Key Ingredients:
- 3% Tranexamic Acid: minimizes the recurrence of discoloration and stubborn brown patches with continued use
- 1% Kojic Acid: naturally produced by certain fungi, kojic acid helps improve skin brightness
- 5% Niacinamide (Vitamin B3): a water-soluble vitamin that has been shown to help reduce the appearance of skin discoloration
- 5% HEPES: a synthetically-derived acid that activates natural enzymes in skin to help break the bonds that bind dead skin cells to the surface for even exfoliation
Key Benefits:
- Features a synergistic blend of anti-discoloration ingredients to reduce the appearance of skin discoloration, improve brightness, and minimize the reoccurrence of discoloration (with continued use)
- 60% average improvement in the appearance of stubborn brown patches
- Paraben-free, fragrance-free, silicone-free, gluten-free, and hydroquinone-free
- Ideal at-home complement to professional skin discoloration treatments, such as chemical peels or non-ablative laser; always consult with a physician for individual regimen recommendations
Clinical Studies:
In a 12-week clinical study*, Discoloration Defense significantly improved the appearance of key skin discoloration markers on Fitzpatrick I-IV skin tones:
- 60% average improvement in the appearance of stubborn brown patches
- 59% average improvement in the appearance of skin discoloration
- 81% average improvement in the appearance of post-acne marks
- 59% average improvement in the appearance of even skin tone
In a 12-week study** on deeper skin tones (Fitzpatrick V-VI), twice-daily application of Discoloration Defense demonstrated a statistically-significant improvement in the appearance of discoloration, post-inflammatory discoloration, and even skin tone:
- 33% reduction in hyperpigmentation at 12 weeks
- 34% reduction in post-inflammatory hyperpigmentation at 12 weeks
Learn more on the blog: How to incorporate this serum into your SkinCeuticals regimen.
*A 12-week, single-center, clinical study was conducted on 50 females, ages 25 to 60, Fitzpatrick I-IV, with mild-to-moderate facial skin discoloration, including stubborn dark spots, post-acne marks and uneven skin tone. Discoloration Defense was applied to the face twice a day in conjunction with a sunscreen. Efficacy and tolerability evaluations were conducted at baseline and at weeks 2, 4, 8, and 12.
**A 12-week, single-center, clinical study was conducted on 51 female subjects, Fitzpatrick V-VI, with visible signs of skin discoloration/hyperpigmentation, including post-inflammatory hyperpigmentation and melasma. Discoloration Defense was applied to the face twice a day in conjunction with a sunscreen. Efficacy and tolerability evaluations were conducted at baseline and at weeks 2, 4, 8, and 12.
Twice daily, apply three to five drops to face. For morning use, apply after a SkinCeuticals vitamin C serum and follow with a SkinCeuticals broad-spectrum SPF 50+ sunscreen and limit sun exposure while using this product. Do not use on irritated or broken skin. If irritation occurs, discontinue use.
Acne: Acne Scars
Application Area: Decollete, Face, Neck
Ideal for these Concerns: Acne, Aging Skin, Free Radical Damage, Hyperpigmentation, Scars, Sun Damage
Hyperpigmentation: Dark Spots, Melasma
Ingredient: Kojic Acid, Niacinamide
Preferences: Clean, Fragrance-Free, Gluten-Free, Paraben-Free, Phthalate-Free, Sulfate-Free
Skin Care: Skin Care Treatments
Skin Care Treatments: Face Serums
Skin Type: Acne-Prone Skin, Combination Skin, Dry Skin, Mature Skin, Normal Skin, Oily Skin, Sensitive Skin
Wellness | External Factors: UV Ray Protectors and Treatments
Aqua/Water, Butylene Glycol, Niacinamide, Hydroxyethylpiperazine Ethane Sulfonic Acid, Glycerin, Tranexamic Acid, Propylene Glycol, Hydroxyethyl Urea, Kojic Acid, Caprylyl Glycol, Allantoin, Chlorphenesin, Xanthan Gum, Disodium Edta.
- Correct
- SkinCeuticals
- 30ml
Frequently Bought Together



Total Price: $290.00
Add both to cart
Customer Reviews
Top Customer Reviews
Where reviews refer to beauty products or supplements, results may vary from person to person. Customer reviews are independent and do not represent the views of Dermstore.
Reward members earn 50 points for every review written on verified purchases.
Discoloration Defense
This goes on the skin so nicely. I cam really see a difference in some hyperpigmentation on my face. Recommend.
Report this reviewA little goes a long way!
This is fantastic and I love that only a little bit is required for the whole face.
Report this reviewBuying on repeat
This does a great job on stubborn dark spots. I am on my third bottle and am sharing with my husband who also loves it.
Report this reviewGreat product!
I have hyperpigmentation and acne prone skin. I love this product! It doesn't make me break out and helps with hyperpigmentation. You don't need a lot, so it lasts a long time.
Report this reviewI specifically use this on my decolletage
Another Skinceuticals product I use to help protect my investment of laser procedures. I specifically use this one on my decolletage because that area needs care, too. As someone trying to look my best, these products do what they are meant for.
Report this reviewHoly grail!
Recommended by my derm and it has been a must for me. I just finished my first bottle and it has actually remove most of the dark spots I had because of years with acne.
Report this reviewAlright
Used entire bottle on a consistent basis, once daily, with my usual daily sunscreen and didn't notice any changes in discoloration. Even purchased a second bottle to see if it needed more time. Still didn't notice any big changes. It didn't irritate my very sensitive skin, which was a plus!
Report this reviewStill testing.
Been using for a few months I love the SkinCeuticals line. Trying this discoloration defense. Not sure how effective it is yet.
Report this reviewFading age spots
Wether it be age spot or sun damage this magical serum is fading them away and quickly ❤️❤️
Report this reviewDiscoloration Defense
I purchase my skin care products from Skin Ceuticals and the Dermstore. The serum products when first opened are a clear light yellow and over time transition to a dark orange color. To my surprise, the product I purchased from the Dermstore was the dark orange color when I first received it..I’m not sure if the cap open or what happened, but I am dissatisfied with my purchase.
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