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SkinMedica Age Defense Retinol Complex .25 (1 fl. oz.)
A retinol-based, night lotion for first-time users of all skin types.
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4 installments of $16.00 with Klarna Learn more
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4 installments of $16.00 with afterpay Learn more
SkinMedica's Age Defense Retinol Complex .25 is formulated to renew the skin's tone and texture without irritating the skin. Retinol helps combat the signs of premature aging while magnolia bark extract soothes inflammation. Ideal for use twice a week to build tolerance to formula.
Key Ingredients:
- Retinol: helps boost collagen production and cell turnover to reduce the appearance of fine lines and deep wrinkles
- PhytoShield™ Complex: an antioxidant complex, enhancing skin texture and minimizing irritation
Key Benefits:
- Enhances skin tone and texture
- Boosts more resilient skin
- Diminishes appearance of fine lines and coarse wrinkles
Apply in the evening after cleansing and toning and before applying your moisturizer. If a retinol product has never been used before, begin twice a week 2-3 days apart, gradually increasing frequency to every other night, and then advancing to each evening or as tolerated. Apply to the entire face. Avoid getting in eyes. If contact occurs, rinse eyes thoroughly with water.
Caution: Do not use if you are pregnant, lactating or planning to become pregnant. Mild redness, peeling and irritation are expected when using this product. Use daily sun protection with SPF 30 or higher and limit sun exposure while using this product and for a week following discontinuation.
Aging Skin: Fine Lines and Wrinkles
Application Area: Decollete, Face, Neck
Ideal for these Concerns: Aging Skin, Free Radical Damage, Hyperpigmentation
Ingredient: Antioxidants, Ceramides, Essential Oils, Herbal Extracts, Niacinamide, Peptides, Retinol, Squalane Oil, Vitamin A, Vitamin E
Moisturizers: Night Cream
Preferences: Clean, Paraben-Free, Phthalate-Free, Sulfate-Free
Skin Care: Moisturizers
Skin Type: Acne-Prone Skin, Combination Skin, Dry Skin, Mature Skin, Normal Skin, Oily Skin, Sensitive Skin
Water/Aqua/Eau, Cetyl Ethylhexanoate, Glycine Soja Oil, Caprylic/Capric Triglyceride, Niacinamide, Polyacrylate-13, Squalane, Retinol, Palmitoyl Tripeptide-8, Dunaliella Salina Extract, Magnolia Grandiflora Bark Extract, Tocopherol, Tocotrienols, Ceramide 3, Bisabolol, Phytosterols, Squalene, Tocopheryl Acetate, Oryza Sativa Bran Cera, Glycerin, Polysorbate 20, Butylene Glycol, Cetyl Palmitate, Laureth-23, Trideceth-6 Phosphate, Sodium Hydroxide, Dicaprylyl Ether, Lauryl Alcohol, Polyisobutene, Dextran, Potassium Sorbate, Disodium EDTA, Phenoxyethanol, Ethylhexylglycerin.
- Retinol
- SkinMedica
SkinMedica Age Defense Retinol Complex .25 (1 fl. oz.)
A retinol-based, night lotion for first-time users of all skin types.
Earn 320 reward points when purchasing this product as a rewards member*
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Free delivery after your first order
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You control the frequency
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No commitment. Cancel or delay
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Payment will be taken every month. months.
$64.00

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4 installments of $16.00 with Klarna Learn more
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4 installments of $16.00 with afterpay Learn more
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SkinMedica's Age Defense Retinol Complex .25 is formulated to renew the skin's tone and texture without irritating the skin. Retinol helps combat the signs of premature aging while magnolia bark extract soothes inflammation. Ideal for use twice a week to build tolerance to formula.
Key Ingredients:
- Retinol: helps boost collagen production and cell turnover to reduce the appearance of fine lines and deep wrinkles
- PhytoShield™ Complex: an antioxidant complex, enhancing skin texture and minimizing irritation
Key Benefits:
- Enhances skin tone and texture
- Boosts more resilient skin
- Diminishes appearance of fine lines and coarse wrinkles
Apply in the evening after cleansing and toning and before applying your moisturizer. If a retinol product has never been used before, begin twice a week 2-3 days apart, gradually increasing frequency to every other night, and then advancing to each evening or as tolerated. Apply to the entire face. Avoid getting in eyes. If contact occurs, rinse eyes thoroughly with water.
Caution: Do not use if you are pregnant, lactating or planning to become pregnant. Mild redness, peeling and irritation are expected when using this product. Use daily sun protection with SPF 30 or higher and limit sun exposure while using this product and for a week following discontinuation.
Aging Skin: Fine Lines and Wrinkles
Application Area: Decollete, Face, Neck
Ideal for these Concerns: Aging Skin, Free Radical Damage, Hyperpigmentation
Ingredient: Antioxidants, Ceramides, Essential Oils, Herbal Extracts, Niacinamide, Peptides, Retinol, Squalane Oil, Vitamin A, Vitamin E
Moisturizers: Night Cream
Preferences: Clean, Paraben-Free, Phthalate-Free, Sulfate-Free
Skin Care: Moisturizers
Skin Type: Acne-Prone Skin, Combination Skin, Dry Skin, Mature Skin, Normal Skin, Oily Skin, Sensitive Skin
Water/Aqua/Eau, Cetyl Ethylhexanoate, Glycine Soja Oil, Caprylic/Capric Triglyceride, Niacinamide, Polyacrylate-13, Squalane, Retinol, Palmitoyl Tripeptide-8, Dunaliella Salina Extract, Magnolia Grandiflora Bark Extract, Tocopherol, Tocotrienols, Ceramide 3, Bisabolol, Phytosterols, Squalene, Tocopheryl Acetate, Oryza Sativa Bran Cera, Glycerin, Polysorbate 20, Butylene Glycol, Cetyl Palmitate, Laureth-23, Trideceth-6 Phosphate, Sodium Hydroxide, Dicaprylyl Ether, Lauryl Alcohol, Polyisobutene, Dextran, Potassium Sorbate, Disodium EDTA, Phenoxyethanol, Ethylhexylglycerin.
- Retinol
- SkinMedica
Customer Reviews
Top Customer Reviews
Where reviews refer to beauty products or supplements, results may vary from person to person. Customer reviews are independent and do not represent the views of Dermstore.
Reward members earn 50 points for every review written on verified purchases.
Love so far
Loving so far. Simple, straightforward instructions for beginning retinol users. Great for first time users!!!
Report this reviewGreat beginner retinol
I have very dry skin that doesn’t seem to love retinol. This product my skin loves! Very gentle yet effective.
Report this reviewWorth the price
This was my first foray into retinol and after four months of use I can see a difference in my skin (I'm in my early 30s.) I'm looking forward to moving to the .5 version after this.
Report this reviewIt’s ok, not amazing not bad
This retinol is okay. I have a hard time adjusting to retinol so it’s been difficult for me to stay consistent and get past the purging phase. It is not I really irritating so that is a huge plus!!!
Report this reviewGood for sensitive skin
This was a good product to introduce my sensitive skin to retinol. I also have dry skin so I need to hydrate extra while using this product. I'm currently limiting use to two times a week. Do not use a strong exfoliant while using this product.
Report this reviewGo-to
This has been my ride or die retinal for years now. It makes the biggest difference in my skin texture and appearance.
Report this reviewGreat Retinol for Beginners
I am new to retinol and this product is perfect for that. I love that SkinMedica has so many increments in strength which allows a new user to slowly build up. I started with applying every third night, am currently using every other night, and will work my way to every night and have not experienced any irritation or adverse effects.
Report this reviewYou need this
This retinol has been a game changer. The 0.25 concentration is perfect and doesn’t irritate my skin. My skin looks younger since I’ve started using it
Report this reviewGood Retinol
Very mild retinol for beginners. Did not cause irritation or dryness.
Report this reviewRetinol
I have been using this for 3 months and have not seen any difference. I’m in my twenties and i have a few acne scars on my face nothing serious. Spots have not faded at all. Not worth the price.
Report this review