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SkinMedica Age Defense Retinol Complex .25 (1 fl. oz.)
A retinol-based, night lotion for first-time users of all skin types.
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4 installments of $16.00 with Klarna Learn more
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4 installments of $16.00 with afterpay Learn more
SkinMedica's Age Defense Retinol Complex .25 is formulated to renew the skin's tone and texture without irritating the skin. Retinol helps combat the signs of premature aging while magnolia bark extract soothes inflammation. Ideal for use twice a week to build tolerance to formula.
Key Ingredients:
- Retinol: helps boost collagen production and cell turnover to reduce the appearance of fine lines and deep wrinkles
- PhytoShield™ Complex: an antioxidant complex, enhancing skin texture and minimizing irritation
Key Benefits:
- Enhances skin tone and texture
- Boosts more resilient skin
- Diminishes appearance of fine lines and coarse wrinkles
Apply in the evening after cleansing and toning and before applying your moisturizer. If a retinol product has never been used before, begin twice a week 2-3 days apart, gradually increasing frequency to every other night, and then advancing to each evening or as tolerated. Apply to the entire face. Avoid getting in eyes. If contact occurs, rinse eyes thoroughly with water.
Caution: Do not use if you are pregnant, lactating or planning to become pregnant. Mild redness, peeling and irritation are expected when using this product. Use daily sun protection with SPF 30 or higher and limit sun exposure while using this product and for a week following discontinuation.
Aging Skin: Fine Lines and Wrinkles
Application Area: Decollete, Face, Neck
Ideal for these Concerns: Aging Skin, Free Radical Damage, Hyperpigmentation
Ingredient: Antioxidants, Ceramides, Essential Oils, Herbal Extracts, Niacinamide, Peptides, Retinol, Squalane Oil, Vitamin A, Vitamin E
Moisturizers: Night Cream
Preferences: Clean, Paraben-Free, Phthalate-Free, Sulfate-Free
Skin Care: Moisturizers
Skin Type: Acne-Prone Skin, Combination Skin, Dry Skin, Mature Skin, Normal Skin, Oily Skin, Sensitive Skin
Water/Aqua/Eau, Cetyl Ethylhexanoate, Glycine Soja Oil, Caprylic/Capric Triglyceride, Niacinamide, Polyacrylate-13, Squalane, Retinol, Palmitoyl Tripeptide-8, Dunaliella Salina Extract, Magnolia Grandiflora Bark Extract, Tocopherol, Tocotrienols, Ceramide 3, Bisabolol, Phytosterols, Squalene, Tocopheryl Acetate, Oryza Sativa Bran Cera, Glycerin, Polysorbate 20, Butylene Glycol, Cetyl Palmitate, Laureth-23, Trideceth-6 Phosphate, Sodium Hydroxide, Dicaprylyl Ether, Lauryl Alcohol, Polyisobutene, Dextran, Potassium Sorbate, Disodium EDTA, Phenoxyethanol, Ethylhexylglycerin.
- Retinol
- SkinMedica
SkinMedica Age Defense Retinol Complex .25 (1 fl. oz.)
A retinol-based, night lotion for first-time users of all skin types.
Earn 320 reward points when purchasing this product as a rewards member*
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Free delivery after your first order
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You control the frequency
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No commitment. Cancel or delay
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Payment will be taken every month. months.
$64.00

$25 SkinMedica Gift


NEOSTRATA Skin Active Triple Firming Neck Cream for Mature Skin 80g

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4 installments of $16.00 with Klarna Learn more
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4 installments of $16.00 with afterpay Learn more
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SkinMedica's Age Defense Retinol Complex .25 is formulated to renew the skin's tone and texture without irritating the skin. Retinol helps combat the signs of premature aging while magnolia bark extract soothes inflammation. Ideal for use twice a week to build tolerance to formula.
Key Ingredients:
- Retinol: helps boost collagen production and cell turnover to reduce the appearance of fine lines and deep wrinkles
- PhytoShield™ Complex: an antioxidant complex, enhancing skin texture and minimizing irritation
Key Benefits:
- Enhances skin tone and texture
- Boosts more resilient skin
- Diminishes appearance of fine lines and coarse wrinkles
Apply in the evening after cleansing and toning and before applying your moisturizer. If a retinol product has never been used before, begin twice a week 2-3 days apart, gradually increasing frequency to every other night, and then advancing to each evening or as tolerated. Apply to the entire face. Avoid getting in eyes. If contact occurs, rinse eyes thoroughly with water.
Caution: Do not use if you are pregnant, lactating or planning to become pregnant. Mild redness, peeling and irritation are expected when using this product. Use daily sun protection with SPF 30 or higher and limit sun exposure while using this product and for a week following discontinuation.
Aging Skin: Fine Lines and Wrinkles
Application Area: Decollete, Face, Neck
Ideal for these Concerns: Aging Skin, Free Radical Damage, Hyperpigmentation
Ingredient: Antioxidants, Ceramides, Essential Oils, Herbal Extracts, Niacinamide, Peptides, Retinol, Squalane Oil, Vitamin A, Vitamin E
Moisturizers: Night Cream
Preferences: Clean, Paraben-Free, Phthalate-Free, Sulfate-Free
Skin Care: Moisturizers
Skin Type: Acne-Prone Skin, Combination Skin, Dry Skin, Mature Skin, Normal Skin, Oily Skin, Sensitive Skin
Water/Aqua/Eau, Cetyl Ethylhexanoate, Glycine Soja Oil, Caprylic/Capric Triglyceride, Niacinamide, Polyacrylate-13, Squalane, Retinol, Palmitoyl Tripeptide-8, Dunaliella Salina Extract, Magnolia Grandiflora Bark Extract, Tocopherol, Tocotrienols, Ceramide 3, Bisabolol, Phytosterols, Squalene, Tocopheryl Acetate, Oryza Sativa Bran Cera, Glycerin, Polysorbate 20, Butylene Glycol, Cetyl Palmitate, Laureth-23, Trideceth-6 Phosphate, Sodium Hydroxide, Dicaprylyl Ether, Lauryl Alcohol, Polyisobutene, Dextran, Potassium Sorbate, Disodium EDTA, Phenoxyethanol, Ethylhexylglycerin.
- Retinol
- SkinMedica
Customer Reviews
Top Customer Reviews
Where reviews refer to beauty products or supplements, results may vary from person to person. Customer reviews are independent and do not represent the views of Dermstore.
Reward members earn 50 points for every review written on verified purchases.
Best retinol for sensitive, dry and acne prone skin
Started slow with once or twice a week and over the course of 6 months built to 4-5 days a week. I did not have dry patches, unless I did 2 nights in a row during Chicago winter, which is incredible. My hormonal acne is gone and my skin is smoother and I can wear makeup without it clinging to 5 dry patches. Life changing! I use hydralonic acid and moisturizer with it for hydration.
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Best Retinol
My skin appears smoother and brighter after using this retinol. The 0.25 concentration is gentle for around my eyes.
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beginner friendly
This retinol is formulated so well. It’s lightweight, absorbs well and no irritation!
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Good on sensitive skin
I’ve tried different retinol brands, but this is my favorite. It goes on smoothly and is well absorbed by my dry/psoriasis patchy skin. I feel like it even improves those patches. This one is a keeper.
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Excellent addition to skincare routine
This is my first time incorporating retinol into my skincare routine so I took the advice I've seen out there about starting with a low concentration which is why I chose the .25 I was skeptical at first about whether I would actually see any sort of results with such a low concentration, but I eased into it by only using it a couple of times a week at first and gradually working up to daily usage at night. The results are subtle, but after a month of usage, I have already noticed an improvement in my skin texture and overall complexion. At no point did I experience excessive dryness or suffer from any adverse side effects. I do make sure to follow it up with a thick moisturizer every night to prevent any dryness and during the day I always put on two layers of sunscreen. Every day I wake up with my skin feeling incredibly soft and glowy and I have noticed that my acne breakouts have reduced significantly. I am super pleased with this product.
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Great
This product is great for a retinol starting out!
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Love so far
Loving so far. Simple, straightforward instructions for beginning retinol users. Great for first time users!!!
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Great beginner retinol
I have very dry skin that doesn’t seem to love retinol. This product my skin loves! Very gentle yet effective.
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Worth the price
This was my first foray into retinol and after four months of use I can see a difference in my skin (I'm in my early 30s.) I'm looking forward to moving to the .5 version after this.
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It’s ok, not amazing not bad
This retinol is okay. I have a hard time adjusting to retinol so it’s been difficult for me to stay consistent and get past the purging phase. It is not I really irritating so that is a huge plus!!!
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