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SkinMedica Age Defense Retinol Complex 0.5 (1 fl. oz.)
A retinol-based, night lotion formulated for retinol users.
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4 installments of $20.00 with Klarna Learn more
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4 installments of $20.00 with afterpay Learn more
SkinMedica's Age Defense Retinol Complex 0.5 enhances the skin's texture to promote a brighter, more youthful complexion. Formulated for skin tolerant to retinol treatments, it stimulates collagen production and enhances faster cell renewal to minimize the appearance of fine lines and wrinkles. Algae extract ensures skin is soft, hydrated and protected against free-radical damage.
Key Ingredients:
- Retinol: smooths and refines skin's texture and enhances radiance
- PhytoShield™ Complex: an antioxidant complex, enhances skin texture and minimizes irritation
Key Benefits:
- Enhances skin tone, texture, and resiliency
- Diminishes appearance of fine lines and coarse wrinkles
- Appropriate for all skin types pre-conditioned by using Retinol Complex 0.25 or another retinoid product
Apply a single pump to face in the evening. If you have never used a retinol product before, begin by limiting use to twice a week, gradually increasing frequency to every other night, and then advancing to each evening or as tolerated. Mild redness, peeling and irritation is expected when using this product. Use daily sun protection with SPF 20 or higher during use of this product. Avoid getting in eyes. If contact occurs, rinse eyes thoroughly with water.
CAUTION: Do not use if you are pregnant, lactating or planning to become pregnant.
Aging Skin: Fine Lines and Wrinkles, Loss of Firmness
Application Area: Decollete, Face, Neck
Ideal for these Concerns: Aging Skin, Free Radical Damage, Hyperpigmentation
Ingredient: Antioxidants, Ceramides, Essential Oils, Herbal Extracts, Niacinamide, Peptides, Retinol, Squalane Oil, Vitamin A, Vitamin E
Moisturizers: Night Cream
Preferences: Clean, Paraben-Free, Phthalate-Free, Sulfate-Free
Skin Care: Moisturizers
Skin Type: Acne-Prone Skin, Combination Skin, Dry Skin, Mature Skin, Normal Skin, Oily Skin, Sensitive Skin
Water/Aqua/Eau, Cetyl Ethylhexanoate, Glycine Soja Oil, Caprylic/Capric Triglyceride, Niacinamide, Polyacrylate-13, Squalane, Retinol, Palmitoyl Tripeptide-8, Dunaliella Salina Extract, Magnolia Grandiflora Bark Extract, Tocopherol, Tocotrienols, Ceramide 3, Bisabolol, Phytosterols, Squalene, Tocopheryl Acetate, Oryza Sativa Bran Cera, Glycerin, Polysorbate 20, Butylene Glycol, Cetyl Palmitate, Laureth-23, Trideceth-6 Phosphate, Sodium Hydroxide, Dicaprylyl Ether, Lauryl Alcohol, Polyisobutene, Dextran, Potassium Sorbate, Disodium EDTA, Phenoxyethanol, Ethylhexylglycerin.
- Retinol
- SkinMedica
Frequently Bought Together



Total Price: $186.00
Add both to cart
SkinMedica Age Defense Retinol Complex 0.5 (1 fl. oz.)
A retinol-based, night lotion formulated for retinol users.
Earn 400 reward points when purchasing this product as a rewards member*
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Free delivery
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You control the frequency
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No commitment. Cancel or delay
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Payment will be taken every month. months.
$80.00

$130 SkinMedica Gift

In stock
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4 installments of $20.00 with Klarna Learn more
-
4 installments of $20.00 with afterpay Learn more
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SkinMedica's Age Defense Retinol Complex 0.5 enhances the skin's texture to promote a brighter, more youthful complexion. Formulated for skin tolerant to retinol treatments, it stimulates collagen production and enhances faster cell renewal to minimize the appearance of fine lines and wrinkles. Algae extract ensures skin is soft, hydrated and protected against free-radical damage.
Key Ingredients:
- Retinol: smooths and refines skin's texture and enhances radiance
- PhytoShield™ Complex: an antioxidant complex, enhances skin texture and minimizes irritation
Key Benefits:
- Enhances skin tone, texture, and resiliency
- Diminishes appearance of fine lines and coarse wrinkles
- Appropriate for all skin types pre-conditioned by using Retinol Complex 0.25 or another retinoid product
Apply a single pump to face in the evening. If you have never used a retinol product before, begin by limiting use to twice a week, gradually increasing frequency to every other night, and then advancing to each evening or as tolerated. Mild redness, peeling and irritation is expected when using this product. Use daily sun protection with SPF 20 or higher during use of this product. Avoid getting in eyes. If contact occurs, rinse eyes thoroughly with water.
CAUTION: Do not use if you are pregnant, lactating or planning to become pregnant.
Aging Skin: Fine Lines and Wrinkles, Loss of Firmness
Application Area: Decollete, Face, Neck
Ideal for these Concerns: Aging Skin, Free Radical Damage, Hyperpigmentation
Ingredient: Antioxidants, Ceramides, Essential Oils, Herbal Extracts, Niacinamide, Peptides, Retinol, Squalane Oil, Vitamin A, Vitamin E
Moisturizers: Night Cream
Preferences: Clean, Paraben-Free, Phthalate-Free, Sulfate-Free
Skin Care: Moisturizers
Skin Type: Acne-Prone Skin, Combination Skin, Dry Skin, Mature Skin, Normal Skin, Oily Skin, Sensitive Skin
Water/Aqua/Eau, Cetyl Ethylhexanoate, Glycine Soja Oil, Caprylic/Capric Triglyceride, Niacinamide, Polyacrylate-13, Squalane, Retinol, Palmitoyl Tripeptide-8, Dunaliella Salina Extract, Magnolia Grandiflora Bark Extract, Tocopherol, Tocotrienols, Ceramide 3, Bisabolol, Phytosterols, Squalene, Tocopheryl Acetate, Oryza Sativa Bran Cera, Glycerin, Polysorbate 20, Butylene Glycol, Cetyl Palmitate, Laureth-23, Trideceth-6 Phosphate, Sodium Hydroxide, Dicaprylyl Ether, Lauryl Alcohol, Polyisobutene, Dextran, Potassium Sorbate, Disodium EDTA, Phenoxyethanol, Ethylhexylglycerin.
- Retinol
- SkinMedica
Frequently Bought Together



Total Price: $186.00
Add both to cart
Customer Reviews
Top Customer Reviews
Where reviews refer to beauty products or supplements, results may vary from person to person. Customer reviews are independent and do not represent the views of Dermstore.
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Unsure
I started with the .25 retinol and I thought it worked great to smooth and brighten and once that finished bought this next level. Now I haven't really seen any continued improvements with this one. I have newer sun spots that aren't lightening and my skin doesn't seem as smooth. I have changed other products like my moisturizer and serums but all this gives me pause as to which products are the real powerhouses.
Report this reviewSkinMedica Age Defense Retinol
Previously enjoyed this retinol but recently changed to a tret product.
Report this reviewBurned my skin
I’ve been using retinol for 10 years every day in the night. I decided to try this brand and it burned my skin. I had to got a post procedure skin serum to heal my burn skin. I can’t tolerate not even sunscreen or moisturizer on my skin right now.
Report this reviewmy holy grail for retinols
I have tried many retinol serums in search for one that is medical grade but not too punishing for the dryness, itching and flakiness that come with it~ and I always go back to SkinMedica retinol skin complex. I look 20 yrs younger as what people say to me, thanks to this, my beauty secret.
Report this reviewGreat product
I have to use this every night! Because of age, I had to go down from 1.0 Retinol to ..5. It works so well for me to keep my skin from discoloration and fine lines!
Report this reviewGreat Product!
Skin Medica is one of the best of the best. This Retinol cream is amazing. Smooth and creamy and perfect for nighttime!
Report this reviewGreat Product
I love this product! I particularly like that the amount of retinol is clearly communicated. This is a retinol concentration I can tolerate and so it works well for me.
Report this reviewMy Favorite Over The Counter Retinol
This is my favorite over-the-counter retinol. It's still very powerful and I typically use an additional heavy moisturizer to protect my skin. This product is powerful enough to make your skin dry, like other strong retinols, but it slightly more moisturizing. I recommend using it with another moisturizing barrier for your first few uses.
Report this reviewsecond time buying it
It is more gentle than skinsceuticals. I just wish it wasnt a pump dispenser (i always feel like there is cream left in the jar you cannot get to.
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