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SkinMedica Age Defense Retinol Complex 0.5 (1 fl. oz.)
A retinol-based, night lotion formulated for retinol users.
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4 installments of $20.00 with Klarna Learn more
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4 installments of $20.00 with afterpay Learn more
SkinMedica's Age Defense Retinol Complex 0.5 enhances the skin's texture to promote a brighter, more youthful complexion. Formulated for skin tolerant to retinol treatments, it stimulates collagen production and enhances faster cell renewal to minimize the appearance of fine lines and wrinkles. Algae extract ensures skin is soft, hydrated and protected against free-radical damage.
Key Ingredients:
- Retinol: smooths and refines skin's texture and enhances radiance
- PhytoShield™ Complex: an antioxidant complex, enhances skin texture and minimizes irritation
Key Benefits:
- Enhances skin tone, texture, and resiliency
- Diminishes appearance of fine lines and coarse wrinkles
- Appropriate for all skin types pre-conditioned by using Retinol Complex 0.25 or another retinoid product
Apply a single pump to face in the evening. If you have never used a retinol product before, begin by limiting use to twice a week, gradually increasing frequency to every other night, and then advancing to each evening or as tolerated. Mild redness, peeling and irritation is expected when using this product. Use daily sun protection with SPF 20 or higher during use of this product. Avoid getting in eyes. If contact occurs, rinse eyes thoroughly with water.
CAUTION: Do not use if you are pregnant, lactating or planning to become pregnant.
Aging Skin: Fine Lines and Wrinkles, Loss of Firmness
Application Area: Decollete, Face, Neck
Ideal for these Concerns: Aging Skin, Free Radical Damage, Hyperpigmentation
Ingredient: Antioxidants, Ceramides, Essential Oils, Herbal Extracts, Niacinamide, Peptides, Retinol, Squalane Oil, Vitamin A, Vitamin E
Moisturizers: Night Cream
Preferences: Clean, Paraben-Free, Phthalate-Free, Sulfate-Free
Skin Care: Moisturizers
Skin Type: Acne-Prone Skin, Combination Skin, Dry Skin, Mature Skin, Normal Skin, Oily Skin, Sensitive Skin
Water/Aqua/Eau, Cetyl Ethylhexanoate, Glycine Soja Oil, Caprylic/Capric Triglyceride, Niacinamide, Polyacrylate-13, Squalane, Retinol, Palmitoyl Tripeptide-8, Dunaliella Salina Extract, Magnolia Grandiflora Bark Extract, Tocopherol, Tocotrienols, Ceramide 3, Bisabolol, Phytosterols, Squalene, Tocopheryl Acetate, Oryza Sativa Bran Cera, Glycerin, Polysorbate 20, Butylene Glycol, Cetyl Palmitate, Laureth-23, Trideceth-6 Phosphate, Sodium Hydroxide, Dicaprylyl Ether, Lauryl Alcohol, Polyisobutene, Dextran, Potassium Sorbate, Disodium EDTA, Phenoxyethanol, Ethylhexylglycerin.
- Retinol
- SkinMedica
SkinMedica Age Defense Retinol Complex 0.5 (1 fl. oz.)
A retinol-based, night lotion formulated for retinol users.
Earn 400 reward points when purchasing this product as a rewards member*
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Free delivery after your first order
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You control the frequency
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No commitment. Cancel or delay
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Payment will be taken every month. months.
$80.00

$130 SkinMedica Gift

In stock
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4 installments of $20.00 with Klarna Learn more
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4 installments of $20.00 with afterpay Learn more
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SkinMedica's Age Defense Retinol Complex 0.5 enhances the skin's texture to promote a brighter, more youthful complexion. Formulated for skin tolerant to retinol treatments, it stimulates collagen production and enhances faster cell renewal to minimize the appearance of fine lines and wrinkles. Algae extract ensures skin is soft, hydrated and protected against free-radical damage.
Key Ingredients:
- Retinol: smooths and refines skin's texture and enhances radiance
- PhytoShield™ Complex: an antioxidant complex, enhances skin texture and minimizes irritation
Key Benefits:
- Enhances skin tone, texture, and resiliency
- Diminishes appearance of fine lines and coarse wrinkles
- Appropriate for all skin types pre-conditioned by using Retinol Complex 0.25 or another retinoid product
Apply a single pump to face in the evening. If you have never used a retinol product before, begin by limiting use to twice a week, gradually increasing frequency to every other night, and then advancing to each evening or as tolerated. Mild redness, peeling and irritation is expected when using this product. Use daily sun protection with SPF 20 or higher during use of this product. Avoid getting in eyes. If contact occurs, rinse eyes thoroughly with water.
CAUTION: Do not use if you are pregnant, lactating or planning to become pregnant.
Aging Skin: Fine Lines and Wrinkles, Loss of Firmness
Application Area: Decollete, Face, Neck
Ideal for these Concerns: Aging Skin, Free Radical Damage, Hyperpigmentation
Ingredient: Antioxidants, Ceramides, Essential Oils, Herbal Extracts, Niacinamide, Peptides, Retinol, Squalane Oil, Vitamin A, Vitamin E
Moisturizers: Night Cream
Preferences: Clean, Paraben-Free, Phthalate-Free, Sulfate-Free
Skin Care: Moisturizers
Skin Type: Acne-Prone Skin, Combination Skin, Dry Skin, Mature Skin, Normal Skin, Oily Skin, Sensitive Skin
Water/Aqua/Eau, Cetyl Ethylhexanoate, Glycine Soja Oil, Caprylic/Capric Triglyceride, Niacinamide, Polyacrylate-13, Squalane, Retinol, Palmitoyl Tripeptide-8, Dunaliella Salina Extract, Magnolia Grandiflora Bark Extract, Tocopherol, Tocotrienols, Ceramide 3, Bisabolol, Phytosterols, Squalene, Tocopheryl Acetate, Oryza Sativa Bran Cera, Glycerin, Polysorbate 20, Butylene Glycol, Cetyl Palmitate, Laureth-23, Trideceth-6 Phosphate, Sodium Hydroxide, Dicaprylyl Ether, Lauryl Alcohol, Polyisobutene, Dextran, Potassium Sorbate, Disodium EDTA, Phenoxyethanol, Ethylhexylglycerin.
- Retinol
- SkinMedica
Customer Reviews
Top Customer Reviews
Where reviews refer to beauty products or supplements, results may vary from person to person. Customer reviews are independent and do not represent the views of Dermstore.
Reward members earn 50 points for every review written on verified purchases.
Loving it so far
I bought my first SkinMedica retinol in the 0.25 back in December, tolerated it well, and decided to move up to the 0.5 for the next bottle. The 0.25 bottle lasted me nearly 3 months, so I'm hoping the 0.5 lasts just as long! I personally have not experienced any irritation from either bottle! My skin is on the drier side and is fairly sensitive/somewhat acne-prone, and my skin seems to love this retinol. I already am noticing much quicker skin turnover and feel like it has helped reduce scarring noticeably already within the first week of use. Wish it weren't as pricey but still very happy!
Report this reviewLOVE
It took my skin the 2 weeks or so to get used to the retinol, but I feel like I have results after a few months! Getting compliments on my skin like never before!
Report this reviewRetinol
I recently upped to this product from the .25 version. It is definitely drying but works well when paired with a thicker moisturizer.
Report this reviewUnsure
I started with the .25 retinol and I thought it worked great to smooth and brighten and once that finished bought this next level. Now I haven't really seen any continued improvements with this one. I have newer sun spots that aren't lightening and my skin doesn't seem as smooth. I have changed other products like my moisturizer and serums but all this gives me pause as to which products are the real powerhouses.
Report this reviewSkinMedica Age Defense Retinol
Previously enjoyed this retinol but recently changed to a tret product.
Report this reviewBurned my skin
I’ve been using retinol for 10 years every day in the night. I decided to try this brand and it burned my skin. I had to got a post procedure skin serum to heal my burn skin. I can’t tolerate not even sunscreen or moisturizer on my skin right now.
Report this reviewmy holy grail for retinols
I have tried many retinol serums in search for one that is medical grade but not too punishing for the dryness, itching and flakiness that come with it~ and I always go back to SkinMedica retinol skin complex. I look 20 yrs younger as what people say to me, thanks to this, my beauty secret.
Report this reviewGreat product
I have to use this every night! Because of age, I had to go down from 1.0 Retinol to ..5. It works so well for me to keep my skin from discoloration and fine lines!
Report this review