Free express shipping when you spend $100+ on your purchase with code SHIP
FREE US Shipping $50+ Auto-Replenishment 15% off First App Order Dermstore Rewards
SkinMedica

SkinMedica TNS Advanced+ Serum (1 fl. oz.)

A powerful anti-aging serum that targets fine lines, deep wrinkles and sagging skin.

Rewards members earn 1475 points on this order. Register & opt in at checkout.

Join Dermstore Rewards

$295.00

Or 4 interest free payments of $73.75 with


In stock | Usually dispatched within 24 hours

Image 1 - Image of a skin serum bottle labeled TNS® ADVANCED+ SERUM with a background of glass beakers, featuring the text Next Generation Skin Rejuvenation and additional claims such as Clinically proven to address sagging skin, Smooths visible coarse wrinkles and fine lines, and Results start in just 2 weeks*.
Image 2 - Image showing a side-by-side comparison of a 60-year-old females face before and after using TNS Advanced+ serum, with the Before image on the left showing visible wrinkles and the After image on the right indicating smoother skin with marked improvements at week 2, alongside text detailing baseline and improvements.
Image 3 - Image shows a cream or gel texture with text highlighting key ingredients for skincare. Visible text includes: Key Ingredients TNS-MR An advanced formula to help you get age-defying results with: + NEXT-GENERATION GROWTH FACTOR BLEND Supports healthy skin functions + INNOVATIVE PEPTIDE COMPLEX Nourishes your skin Renessence (RSC) Advanced Specifically designed to support the results of the growth factor blend and includes: + MARINE EXTRACT Supports skin’s renewal process + GREEN MICROALGAE Supports collagen and elastin levels.
Image 4 - A sleek bottle of SkinMedica TNS Advanced+ Serum is displayed next to a small amount of the serum on a light background, with the text stating that in a clinical study, after 12 weeks, patients using the serum felt they looked up to 6 years younger.
Image 5 - A pair of hands holds a cosmetic bottle with instructions on its use, including details on when and how to apply the product, and visible text that reads: How to Use, WHEN TO APPLY, In the morning and evening after cleansing and toning, HOW TO APPLY, Before applying, invert and tap the bottom of the bottle, Remove the cap and press on the center of the pump to dispense onto the back of your hand using a bunny finger application, Blend the product together before applying, Avoid getting in eyes. If contact occurs, rinse eyes thoroughly with warm water.
Image 6 - Image of SkinMedica products arranged on a light background, including an AHA/BHA Exfoliating Cleanser, TNS Advanced+ Serum, Instant Bright Eye Cream, HA⁵ Hydra Collagen Replenish + Restore Hydrator, and Essential Defense Mineral Shield Broad Spectrum SPF 35 Sunscreen, with the text Complete Your SkinMedica Method Routine above them.Image 7 - Close up of a womans face with text that reads Pioneer of regenerative skincare With over 25 years of innovation, SkinMedica develops professional-grade products for every step in a complete skincare routine

Delivery & Returns
Free delivery is available on all orders over $50. Please see our shipping information page for all available delivery options.
If I'm not completely happy with my item?
Please see our returns policy.
*points earned on final checkout price, after any applied discounts.

Frequently Bought Together

SkinMedica TNS Advanced+ Serum (1 fl. oz.)

This item

SkinMedica TNS Advanced+ Serum (1 fl. oz.)

$295.00

Total Price:

$479.00

Other Customers Bought

Customer Reviews

4.56 stars out of a maximum of 5

5 stars rating 445 reviews

4 stars rating 84 reviews

3 stars rating 32 reviews

2 stars rating 13 reviews

1 stars rating 19 reviews

Top Customer Reviews

Reviews and results may vary from person to person. Customer reviews are and do not represent the views of The Hut Group.

Need more time

4 stars out of a maximum of 5

I've been using this for about a month and haven't seen a remarkable difference, though I'm invested in using it for another month or two. Layers nicely with other serums/products.

by Liz Verified Purchase

Was this helpful?

Wanted to love it.

1 stars out of a maximum of 5

Just not impressed with this product. It certainly hasn't evened out my skin tone and I feel like it dries out my skin. No noticeable improvement after a month with wrinkles or fine lines. For the cost I definitely would not purchase again. After reading all the reviews, I was hopeful I really wanted this to work ... but this is just not working for me.

by Patty Verified Purchase

Was this helpful?

Not sure

5 stars out of a maximum of 5

This was recommended to me by my dermatologist, but I didn’t see any drastic changes.

by Alissa

Was this helpful?

Unsure

3 stars out of a maximum of 5

I’m not sure if I can tell a difference at all with this. It feels smooth and nice, but it is SO expensive and the way I’ve heard it be hyped up, I was expecting to notice more of anything. 

by Alexa Verified Purchase

Was this helpful?

Great aerum

5 stars out of a maximum of 5

Have noticed quite a difference since using this product. My shin is much better hydrated and blemish free.

by Lynn Verified Purchase

Was this helpful?

SkinMedica TNS Advanced Serum

5 stars out of a maximum of 5

I purchased this from Dermstore after reading reviews in a magazine about various skincare products. I then visited my dermatologist for a health checkup and saw that their spa used the Skinmedica line. I thought I would then give this a try. I am on my second bottle and I can tell you that this is moisturizing and I do see improvement in some of my facial lines. I also receive compliments from people telling me I look rested and my skin looks healthy. I have been diligent about applying twice a day. One bottle last me approximately 3 months. Worth the money.

by Lisa Verified Purchase

Was this helpful?

Obsessed!

5 stars out of a maximum of 5

I was already using/loving SkinMedica & several of my favorite products are in the TNS line. This is my first time using the TNS Advanced+ Serum & I love it! It’s been a couple of weeks now & I continue to use as directed in combination w/ my HA5 & I'm hooked. My skin is visibly more hydrated, plumper, more even & brighter.  Totally worth it & I highly recommend. 

by Jas Verified Purchase

Was this helpful?

Pricey but bit the bullet

5 stars out of a maximum of 5

My aesthetician recommended this for me. If you buy it on recurring order, it's much easier to afford, and you can adjust your next shipment to work with your needs, so doesn't make sense not to. I am seeing nice results in just a couple weeks, and can't wait to see in a few months. For those who have trouble with the dual chamber pump, in order to ensure that it is coming out of both chambers evenly, pump slowly to gauge the dispensing and tilt it more to the side it may not be coming out of to get both to dispense evenly..very simple and not always necessary.

by Suzi Verified Purchase

Was this helpful?

Good Skin Improvement

4 stars out of a maximum of 5

I have searched for products that target lines and wrinkles and provide an overall refresh for  mature skin.  Since using this product I notice a more youthful appearance and a decrease in visibility of lines and wrinkles. However, I do not like the packing.   I find with this type of container and others that do not allow you to directly access product, there is often product left in the container that one cannot access. This a problem for expensive products such as this one.

by Diane Verified Purchase

Was this helpful?

Smoother skin

5 stars out of a maximum of 5

Since using this product, I have noticed that my skin is smoother and tighter. The serum is also very soothing.

by Sam Verified Purchase

Was this helpful?