Earn 2x points on SkinMedica | TWO Free Gifts when you spend $200+ on your purchase. SHOP NOW
FREE US Shipping $50+ Auto-Replenishment 15% off first App Order Dermstore Rewards
SkinMedica

SkinMedica TNS Advanced+ Serum (1 fl. oz.)

A powerful anti-aging serum that targets fine lines, deep wrinkles and sagging skin.

Rewards members earn 2950 points on this order. Register & opt in at checkout.

Join Dermstore Rewards

$295.00

Or 4 interest free payments of $73.75 with


In stock | Usually dispatched within 24 hours

Image 1 - Image of a skin serum bottle labeled TNS® ADVANCED+ SERUM with a background of glass beakers, featuring the text Next Generation Skin Rejuvenation and additional claims such as Clinically proven to address sagging skin, Smooths visible coarse wrinkles and fine lines, and Results start in just 2 weeks*.
Image 2 - Image showing a side-by-side comparison of a 60-year-old females face before and after using TNS Advanced+ serum, with the Before image on the left showing visible wrinkles and the After image on the right indicating smoother skin with marked improvements at week 2, alongside text detailing baseline and improvements.
Image 3 - Image shows a cream or gel texture with text highlighting key ingredients for skincare. Visible text includes: Key Ingredients TNS-MR An advanced formula to help you get age-defying results with: + NEXT-GENERATION GROWTH FACTOR BLEND Supports healthy skin functions + INNOVATIVE PEPTIDE COMPLEX Nourishes your skin Renessence (RSC) Advanced Specifically designed to support the results of the growth factor blend and includes: + MARINE EXTRACT Supports skin’s renewal process + GREEN MICROALGAE Supports collagen and elastin levels.
Image 4 - A sleek bottle of SkinMedica TNS Advanced+ Serum is displayed next to a small amount of the serum on a light background, with the text stating that in a clinical study, after 12 weeks, patients using the serum felt they looked up to 6 years younger.
Image 5 - A pair of hands holds a cosmetic bottle with instructions on its use, including details on when and how to apply the product, and visible text that reads: How to Use, WHEN TO APPLY, In the morning and evening after cleansing and toning, HOW TO APPLY, Before applying, invert and tap the bottom of the bottle, Remove the cap and press on the center of the pump to dispense onto the back of your hand using a bunny finger application, Blend the product together before applying, Avoid getting in eyes. If contact occurs, rinse eyes thoroughly with warm water.
Image 6 - Image of SkinMedica products arranged on a light background, including an AHA/BHA Exfoliating Cleanser, TNS Advanced+ Serum, Instant Bright Eye Cream, HA⁵ Hydra Collagen Replenish + Restore Hydrator, and Essential Defense Mineral Shield Broad Spectrum SPF 35 Sunscreen, with the text Complete Your SkinMedica Method Routine above them.

Delivery & Returns
Free delivery is available on all orders over $50. Please see our shipping information page for all available delivery options.
If I'm not completely happy with my item?
Please see our returns policy.
*points earned on final checkout price, after any applied discounts.

Frequently Bought Together

SkinMedica TNS Advanced+ Serum (1 fl. oz.)

This item

SkinMedica TNS Advanced+ Serum (1 fl. oz.)

$295.00

Total Price:

$479.00

Other Customers Bought

Customer Reviews

4.55 stars out of a maximum of 5

5 stars rating 441 reviews

4 stars rating 82 reviews

3 stars rating 32 reviews

2 stars rating 12 reviews

1 stars rating 20 reviews

Top Customer Reviews

Reviews and results may vary from person to person. Customer reviews are and do not represent the views of The Hut Group.

Good quality serum

4 stars out of a maximum of 5

Absorbs well into skin and if used diligently, it does seem to be effective as my forehead lines are slightly less prominent. Will continue to use. 

by Witherwings Verified Purchase

Was this helpful?

Expensive, disappointing

1 stars out of a maximum of 5

I was really excited to try this serum based on all the reviews I had been reading, but I have to say that so far it has done nothing for my skin; I haven't seen any differences. The container barely has any serum and is a very steep price, and the smell was a bit nauseating to me as well.

by Rae Verified Purchase

Was this helpful?

Transformative!

5 stars out of a maximum of 5

This is by far the most expensive product I have ever used. At 35, with sun-damaged skin and many fine lines that are deepening into true wrinkles around the eyes, I decided to give this a try. It is far and a way the most powerful, transformative product I have ever used - and I’m only 2 weeks in to daily usage. Fine lines appear diminished, pore size is reduced, and my skin is more luminous and moisturized than ever before - with any serum, moisturizer, or combo product I have ever used. Real results were an honest surprise to me, and I can’t wait to see what happens after using this for longer. It’s pricey, but I literally feel the years ticking back on the clock and that feels worth it to me.

by C Verified Purchase

Was this helpful?

Happy customer

4 stars out of a maximum of 5

Very pleased with this product. Using daily only 1x per day and bottle last 3 solid months. Helps me to feel better about the cost. Definitely feel it’s worth the money though. More impact with just one product

by Kristen Verified Purchase

Was this helpful?

The BEST product

5 stars out of a maximum of 5

This product is the absolute best for improving the appearance of your skin.  I work in the skincare industry and swear by this product for visible results almost immediately.

by Darlene Verified Purchase

Was this helpful?

Still waiting on big magic but I have noticed results

4 stars out of a maximum of 5

I have seen some improvement, more noticeable improvement than I do with most products. However, for this price I am hoping that by the end of the bottle I see a little bit more before I decide to make the investment again. 

by Kaitlin Verified Purchase

Was this helpful?

The Very Best

5 stars out of a maximum of 5

TNS Advanced Serum is unlike anything I've ever used. Don't ever want be without it, and I highly recommend.

by Allison Verified Purchase

Was this helpful?

Highly recommend this serum for non retinol nights!

5 stars out of a maximum of 5

I love this serum! I use it on alternating nights when I am not using my retinol during my nighttime routine!! I always wake up with super soft and glowing skin in the morning! It is worth the money for me!! I put it on after double cleansing, and follow up with the triple restore moisturizer from skin ceuticals. I have combination skin that is more on the oily side and I have had no breakouts while using this product!

by Natasha Verified Purchase

Was this helpful?

Time will tell

5 stars out of a maximum of 5

I have been using SkinMedica's TNS Essential Serum for a while but recently decided to give the Advanced+ Serum a try. While I can't tell how effective it is compared to the sister product, I do like the feel and that it doesn't react with my skin. It's very expensive so hopefully it's helping!

by Alina Verified Purchase

Was this helpful?

Years of consistent use has worked!!

5 stars out of a maximum of 5

I get compliments on my complexion quite often.  They asked what I use?  I’m always happy to say SkinMedica TNS Advanced Serum!   After a few months of use, I could tell a big difference in the smoothness of my skin. I have tried other facial products in the past but none have been as helpful as this one.  I wish the cost were less so I always buy on sale.   I highly recommend!

by Bronda Verified Purchase

Was this helpful?