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Showdown: A.G.E Interrupter Advanced vs Triple Lipid Restore 2:4:2

Showdown: A.G.E Interrupter Advanced vs Triple Lipid Restore 2:4:2
Writer and expert9 months ago
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Let's face it, we all want to look our best as we age and adding an anti-aging cream to your daily skincare routine can help. Thankfully, there's no shortage of options to choose from. But choosing one that actually makes a visible difference AND addresses the particular signs of aging you're concerned about is a different story. With no shortage of science-backed formulas, SkinCeuticals has two particularly highly-praised creams: A.G.E Interrupter Advanced and Triple Lipid Restore 2:4:2; both of which target two different natural processes in the skin known to accelerate visible signs of aging. These corrective creams feature powerful ingredients in high concentrations that can improve the appearance of existing concerns and help prevent new ones from forming. So, whether you're just starting to see the first signs of aging, or you are looking to combat more advanced signs, read on to find out which cream might be the perfect addition to your daily skincare lineup.


A.G.E Interrupter Advanced for collagen decline and deep wrinkles.


Collagen is a vital structural protein that provides our skin with a bouncy, firm, and youthful look. While collagen production naturally slows down with age, other key processes also impact collagen decline and accelerate visible signs of aging, one of which is Glycation. This natural, multi-phase process occurs when excess sugar molecules bind to proteins, including collagen and elastin, forming damaging byproducts known as advanced glycation end-products or A.G.E.s. Glycation causes once flexible and resilient collagen fibers to become rigid and brittle, ultimately leading to wrinkling, dullness, and sagging. But fear not, A.G.E Interrupter Advanced is a groundbreaking corrective cream designed to target the complete multi-phase glycation process known to visibly age skin. Backed by 15+ years of glycation research and expertise, A.G.E Interrupter Advanced is formulated with a high concentration of potent ingredients like Proxylane and wild fruit flavonoids that work to support skin’s integrity while defending against glycation. The newly reformulated breakthrough formula also includes new ingredients like glycyrrhetinic acid, HEPES, and niacinamide, which work together to enhance skin's natural radiance, promote even cell turnover, and support the skin's moisture barrier. Not only does this formula help to interrupt the glycation process, it also visibly smooths five key wrinkle types, including forehead wrinkles, nasolabial folds, marionette wrinkles, glabellar wrinkles, and crow's feet. Incorporating an anti-glycation formula like A.G.E Interrupter Advanced into your daily routine can help address collagen decline to visibly smooth wrinkles and restore skin firmness and defend against future signs of aging caused by AGE formation.

To use: Twice daily, massage a thin, even layer of A.G.E. Interrupter Advanced onto the entire face, neck, and chest.

If using in the morning, apply after a SkinCeuticals vitamin C antioxidant serum and before a sunscreen.

If using with a retinol at night, apply after retinol application.

Triple Lipid Restore 2:4:2 for skin barrier support and age-related lipid loss.


Triple Lipid Restore 2:4:2 is a patented corrective cream that addresses age-related lipid loss while supporting healthy skin barrier function. The skin barrier is a critical component of overall skin health and is made up of essential lipids such as ceramides, cholesterol, and fatty acids. These lipids work together to create a protective barrier that prevents moisture loss and protects the skin from external stressors. Unfortunately, as we age, our skin becomes more vulnerable to depletion of these essential lipids, leading to a weakened skin barrier and visible signs of aging. If you're experiencing skin roughness, uncomfortable tightness, dullness, or loss of facial fullness, incorporating Triple Lipid Restore 2:4:2 into your daily skincare regimen can help address these concerns and more. This innovative formula boasts an optimal and patented ratio of 2% ceramides, 4% natural cholesterol, and 2% fatty acids, which work together to restore skin lipids and improve the look of skin fullness, texture, and overall radiance. The unique lipid combination helps support the skin barrier and nourish dry or dehydrated skin, while the fast-absorbing, lightweight luxurious texture makes it ideal for all skin types - even sensitive skin. By incorporating Triple Lipid Restore 2:4:2 into your daily skincare routine, you can address age-related lipid loss and maintain a healthy skin barrier, leaving your skin looking and feeling rejuvenated.

To use: Apply a small amount of Triple Lipid Restore 2:4:2 once or twice daily to face, neck, and chest.

If using in the morning, apply after a SkinCeuticals vitamin C antioxidant serum and before a SkinCeuticals sunscreen.

If using with a retinol at night, apply after retinol application.

If you are concerned about or experiencing both age-related skin changes described above, you have the option of layering both formulas for enhanced results! Here’s how:

  1. Apply your antioxidant and corrective serums
  2. Apply A.G.E Interrupter Advanced
  3. Apply Triple Lipid Restore 2:4:2

It can be difficult to decide which anti-aging cream is best suited for you and your concerns and there are so many factors to consider such as age, lifestyle, visible concerns, and skin type. Knowing how a formula works, what it addresses, and the benefit of daily application is key to achieving your best results.

Writer and expert
View dermstore-editors's profile
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